Sophie Javerzat Professor of Genetics

Course and current status

Employment history

1992-1995 :  Postdoctoral fellow. MRC Human Genetics Unit, Edinburgh, UK

1995- 1996 : Hospital assistant lecturer, Centre de Procréation Médicalement Assistée et Laboratoire de Biologie Cellulaire, Centre Hospitalier Universitaire de Bordeaux.

1996-2007 : Associate Professor Université Bordeaux1

2014 - june 2019 : Associate dean, in charge of training programmes in Sciences and Technology. University of Bordeaux

2007 - present : Full Professor of Genetics, University of Bordeaux, CNU : 65

2019 - present : Task officer for Sciences and Technology. Continuous improvement towards Quality Education

Education and diplomas

1992 : Doctoral degree. Health Sciences. Université de Bordeaux 2. Laboratoire de Rétrovirologie, INSERM U328

2005 : Accreditation to conduct research. Université de Bordeaux 1. Laboratoire des Mécanismes Moléculaires de l’Angiogenèse

Main research training

1992-1995 : Postdoctoral fellow. MRC Human Genetics Unit, Edinburgh, UK

Publications          

            major references : http://publicationslist.org/s.javerzat

Scientific committees and scientific advisory boards

2010-2017 : Elected Member of the Scientific board Ligue régionale contre le cancer

2011-2013 : Elected Member of the National Council of Universities, France

2012-2014 : Elected Member of the Scientific Council of University, Bordeaux 1

2014-2019 : Elected Member of the Council of Sciences & Technology Collegium, University Bordeaux

2018-present : Elected Member of the training and campus Council, CFVU, University Bordeaux

2018-present : Elected Member of the Life Sciences training department, UF de Biologie, Université de Bordeaux

Collective responsabilities

Task officier :  Continuous improvement towards Quality Education, Sustainable Development on campus and in training programmes - Pedagogical transformation, associated digital tools

  • Coach a community of trainers around transformation and educational innovation.
  • Organize educational workshops open to all to share experiences and good practices
  • Contribute to the reflection of UB for reaching sustainable development goals, in connection with training and educational transformation.
  • Participate in the various stages of development of digital tools dedicated to pilot training and training programmes.
Additional contributions

* Regular invited speaker and consultant on bioethics, eg : DNA profiling, human embryo manipulation, assisted reproduction

For instance : La gestation pour autrui (approche médicale) by Sophie Javerzat, les cahiers de la justice, 2016 p 203-205

* I signed the #ScientistsWarningToHumanity

https://academic.oup.com/bioscience/article/70/1/8/5610806

Scientific summary

After 3 years of post-doc in Edinbugh MRC Human Genetics Unit, my initial expertise is in functional genetics and positional cloning. Since I was recruited in Bordeaux, my main research has aimed at confirming the angiogenic function of FGF pathway in vivo by transgenesis, then identifying new actors of angiogenesis by transcriptomic screenings in model systems. To this end, new models have been designed (eg Hagedorn et al., 2005) allowing the identification of key tumor genes regulated during the angiogenic switch, which were further investigated for their functional implication in tumorigenesis, tumor angiogenesis and patient survival. For 15 years I have focused on the challenging case of glioblastoma, and its remarkable abilities to evade anti-angiogenic therapy. I designed new models to mimic these properties in vivo and asked whether combined targeting therapy can efficiently control evasive resistance. I further contributed to multimodal imaging of glioblastoma focusing on the specificities of angiogenic versus cooptive tumors.

In 2019, I decided to go back to my roots and moved to INSERM U1211 Bordeaux to join a research group on genetics of albinism. I now contribute to the functional validation of new pathogenic allelic variants and am mostly interested in the developmental defects that impair retinal development and vision in patients with albinism.

LAST PUBLICATION  https://www.nature.com/articles/s41436-020-00997-8

Keywords : genetics, embryology, pigment cells, eye development, animal models, transgenic mice, zebrafish, pathological tissue imaging



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