CV Science

Nicolas Moniaux Ph.D. Health and Life Sciences

Course and current status

Since 2011: INSERM senior scientist (CR1), UMR785 Inserm/University paris XI, Hepatobiliary center, Paul Brousse Hospital, Villejuif (France)

2007-2011: INSERM Young Investigator, UMR785 Inserm/University paris XI, Hepatobiliary center, Paul Brousse Hospital, Villejuif (France)

2003-2007: Assistant Professor, Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE (USA)

2002-2003: Research Associate, Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE (USA)

1999-2003: Postdoc fellow, Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE (USA)

Scientific summary

The aim of my research program is to study the mechanistic networks involved in the hepatoprotection response to liver injury, to characterize cell populations participating in liver regeneration during severe acute and fulminant hepatitis, and to develop therapeutic and diagnostic innovations based on our preclinical studies. Among the factors involved in these processes, we focus on a C-type lectin, called HIP/PAP, which is a potent liver paracrine growth factor harboring mitogenic, anti-apoptotic, anti-oxidant, and survival properties. It favors liver regeneration after partial hepatectomy and has a preventive and a curative effect against acetominophen- or Jo2- (an agonist of Fas/CD95) induced fulminant hepatitis in mice. This research program leads us to investigate the interaction between oxidative stress and extracellular matrix as a key regulator of liver physiopathology.