Thierry Huby
  • E-mail :[email]
  • Phone : +33 1 42 17 78 60
  • Location : Paris, France
Last update 2011-09-16 11:24:33.829

Thierry Huby INSERM Research Scientist; PhD in Biochemistry

Course and current status


Ph.D. in Biochemistry - 1997
University of Paris Diderot -Paris 7
Advisor: Dr Joëlle Thillet (DR2 INSERM)

Thesis: ‘Structure-fonction relationship of lipoprotein (a) : Studies of the structural domains of apolipoprotein (a) and their fibrin binding capacities’

B.S. (Proteins : structure, functions and engineering) 1992
University of Paris Diderot -Paris 7; Pasteur Institute, Paris

Master Degree (Microbiology and Virology Major) 1989
University of Paris Diderot -Paris 7



INSERM Research  Scientist 2000 - present
National Institute of Health and Medical Research (INSERM), Paris - France
INSERM Unit 551 (2000 – 2008); INSERM Unit 939 (2009 – present); Director: Philippe Lesnik
Research topics: Structure-Function studies of Scavenger Receptor SR-BI – Relevance to cholesterol metabolism, innate immunity and atherosclerosis.  

Postdoctoral Fellow 1997-1999
Lawrence Berkeley National laboratory, Berkeley - U.S. Department of Energy - University of California
Genome Sciences Department
Advisor: Edward M Rubin
Research topics: In vivo studies of apo(a) binding properties to the vascular wall - Control of Apo(a) gene expression

Doctoral Fellow 1993-1997
National Institute of Health and Medical Research (INSERM), Paris - France
INSERM Unit 551; Director: John Chapman
Advisor: Dr Joëlle Thillet
Research topic: Structure-fonction studies of lipoprotein(a)


Grant from the French National Research Agency 2007-2011 (GENOPATH), Principal Investigator

Grant from the Heart and Artery Foundation 2006-2009, Principal Investigator

International HDL Research Award - Pfizer/USA 2005-2007

Bayer-Pharma/Arcol 1999 Post-doctoral fellowship

American Heart Association post-doctoral fellowship, Western Affiliate (1998 & 1999)

Doctoral fellowship from the French Department of Education and Research (1993-96)

Parke Davis/Arcol and Phillipe Foundation post-doctoral fellowships (1996)

Scientific summary

I am a research scientist working at the INSERM institute since 2000 with a background in basic research in lipoprotein metabolism and atherosclerosis. My global objective is to develop and study mouse models to dissect in vivo the physiopathological mechanisms that contribute to the progression or regression of the disease. In the last years, I have mainly focused my research on evaluating the tissue-specific role of a receptor, the scavenger receptor SR-BI, in mediating the anti-atherogenic activities of the High-Density Lipoprotein HDL and modulating the transport of the HDL-cholesterol throughout the body. With the development of specific conditional Knock-Out and transgenic mice, I am also evaluating the specific contribution of this HDL-receptor SR-BI expressed in endothelial cell and macrophages to the atherosclerotic process and its role in innate immunity (macrophages and dendritic cells) as a Pattern Recognition Receptor.

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