Stéphane Savary
  • E-mail :[email]
  • Phone : +33 3 80 39 62 73
  • Location : Dijon, France
Last update 2017-11-14 11:17:24.59

Stéphane Savary Pr.

Course and current status

Stéphane SAVARY

LAb. BioPeroxIL - EA7270 University of Bourgogne

6, Bd Gabriel, F-21000 Dijon, France



   Since 2012 : Professor of Biochemistry and Molecular Biology, IUT Dijon,

Head of the group “ABCD transporters and X-ALD”, Lab. BioperoxIL, EA7270 University of Bourgogne

1998-2012 : Associate Professor, Biochemistry and Molecular Biology, IUT Dijon

1996-1998 : Assistant Professor, Molecular Biology, University of Tours, Postdoc in the Research Institute of Insect Biology, Genomic relationship between the wasp Cotesia congregata and its symbiotic polydnavirus.



2004 - Habilitation to Supervise Researches, Univeristy of Bourgogne,  “Cloning and characterization of the ABCD2 gene: therapeutic hope for adrenoleukodystrophy”

1996 - PhD. Immunology, University of the Mediterranean Marseille, France, CIML, Identification and characterization of novel ABC transporters in mammals.

1993 - MS Immunology, University of the Mediterranean Marseille, France

1989-1992 - BS,MS Biochemistry, University of the Mediterranean Marseille, France



Supervisor of 9 Master students since 1999

Supervisor of 6 PhD students since 1999



- Elected to the Comission of human ressources of the IUT of Dijon since 2013

- Elected to the Scientific Council of the IUT of Dijon 2006-2012

- President of the AEP-Bio (Association for the Study of Peroxisomes) whose aim is to animate a scientific network and organize scientific meeting every two years on peroxisomal themes.

- Co-organizer of the 3rd OEPM (Dijon, 2012), of the 29th Forum of Young Researchers SFBBM (Dijon, 2002)

- Organizer of the 11th (Dijon, 2004) and 12th (Paris, 2006) meeting of AEP-Bio

Scientific summary

Cloning of novel ABC transporters in mammals

ABCA1 - Tangier Disease, Cholesterol efflux

ABCB7 - Sideroblastic Anemia

ABCG1 - Cholesterol efflux

ABCD2 - Closest homolog of ABCD1 which is associated to X-linked adrenoleukodystrophy


ABCD2, a therapeutic target for X-ALD

Transcriptional regulation of ABCD2

PPARalpha pathway, fibrates, fatty acids

DHEA, Thyroid hormone and thyromimetics as inducers

Phenyl butyrate and chromatin remodeling

LXR antagonists


Structure-function analysis of ABCD2

Substrate specificity

Functional redundancy



Microglia and physiopathogenesis of X-ALD

Establishment of BV2 microglial mutant cell lines

CRISPR-mediated mutations of ABCD1, ABCD2 and ACOX1

Biochemical and functional characterization (lipids, membrane properties, phagocytosis, cytokines, ...)

Co-culture with oligodendrocytes (link between microglial peroxisomes and demyelination)

Co-culture with T lymphocytes (link between microglial peroxisomes and immune response)

Image d’exemple