2010-present : Research Associate CR1 INSERM - in the group « Regeneration, Pathophysiology & Therapeutic Approaches: Cellular models » in the Myology Research Center in Paris directed by Gillian Butler-Browne, Paris, France. Oculopharyngeal muscular dystrophy: physiopathological mechanisms and therapeutic strategies
2005-2009 : Post-doctoral training in the School of biological Sciences directed by Pr. George Dickson, Royal Holloway, university of London, United Kingdom. Developpement of gene therapy strategies for muscular dystrophies
2002-2005 : PhD in the Chemical and genetic pharmacology laboratory directed by Daniel Scherman, University of Paris Descartes, Paris, France. Study, regulation and application of in vivo gene transfer by electrotransfer.
I am a Research Associate INSERM since 2010 - in the group « Regeneration, Pathophysiology & Therapeutic Approaches: Cellular models » within the Myology Research Center in Paris directed by Gillian Butler-Browne. I am working on a rare autosomal dominant inherited disease called Oculopharyngeal muscular dystrophy (OPMD). OPMD is due to a short abnormal triplet expansion in the PABPN1 gene (polyA binding protein nuclear 1) and is mainly characterized by progressive weakness of pharyngeal, eyelid and limb muscles. My goals are 1) to improve our understanding of the physiopathological mechanisms and 2) to develop new gene- and cell-based therapeutic approaches for this disease.