LOBACCARO JEAN-MARC A.
Date of birth: December 27th, 1965.
Current Position: Professor, PR1, Université Blaise-Pascal, Clermont 2, France.
1992-1996: Post-doctoral Fellow; INSERM U439, Montpellier, France
1997-1999 Research Associate Howard Hughes Medical Institute, Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX
September 1st 1999: Professor, PR2, Université Blaise-Pascal, Clermont 2, France.
September 1st 2008: Professor, PR1, Université Blaise-Pascal, Clermont 2, France.
1995: Henning Andersen Prize 34th Annual Meeting of the European Society for Pædiatric Endocrinology (ESPE) (Edinbourgh, GB)
1996: Henning Andersen Prize 35th Annual Meeting of the ESPE (Montpellier, France)
1996: Young Inverstigator Award of the French Society of Endocrinology. 1998: Travel Award 80th Annual Meeting of the Endocrine Society (New-Orleans, LA).
2002: Prix poster V Congresso Società Italiana di Andrologia Medica (Catania, I).
2000-2010: Fondation BNP-Paribas/FRM: 150 000 €
2006 and 2008: Ligue Auvergne contre le Cancer: 36 000 €
2007-2009: ANR Santé et Environnement “Endisrupt”: 54 000 €
2006 and 2008: Cancéropôle CLARA: 26 000 €
2010-2011: Bourse fixe ARC: 50 000 €
Activity in the management of science:
Number of publications in peer reviewed journals:
About 110 publications in peer reviewed periodics.
87 of these are referenced in PubMed (Lobaccaro J*).
H index = 21
The aim of our group is to understand and discriminate the respective roles of the lipid related nuclear receptors (namely LXR, FXR and SHP) in the control of the endocrine activity. We plan to use complementary as well as parallel approaches to answer these questions. These investigations need: i) the use of the mouse models we already have in the lab (lxr-/-, fxr-/- and shp-/- mice) (coll. Johan AUWERX, EFPL, Lausanne); ii) the analysis of the cellular activity on pertinent cell models; iii) the study of the molecular mechanisms of the LXR on the promoters of their target genes.
From our previous published works it clearly appears that the network LXR-FXR-SHP, abundantly studied in the liver, has also a significant role in testis and prostate physiology and pathology. This project is based on several local collaborations within the GReD unit, the Research Center for Human Nutrition-Auvergne (CRNH-Auvergne) that we joined 4 years ago and the research cancer program of the Cancéropôle Lyon-Auvergne-Rhône Alpes (CLARA).