Ariane Abrieu
  • E-mail :[email]
  • Phone : +33 4 34 35 95 52
  • Location : Montpellier, France
Last update 2014-08-07 12:37:58.502

Ariane Abrieu Ph. D. Health Biology

Course and current status

• 2008-Present: Associate Professor at CRBM, Montpellier, France.

• 2002-2008: Assistant Professor at CRBM, Montpellier, France.

• 1997-2001: Post-doctoral position in Prof. Don W. Cleveland laboratory, Ludwig Institute for Cancer Research, La Jolla, U.S.A. Role of the kinetochore associated kinesin CENP-E in the mitotic checkpoint.

• 1993-1997: Ph. D. directed by Prof. Marcel Dorée, CRBM, Montpellier, France. Control of the cell cycle by Cdk-cyclin and MAPK in Xenopus eggs.

Scientific summary

Our research is focused on mitosis: how protein kinases and mitotic kinesins regulate (i) the assembly and disassembly of the mitotic spindle, (ii) chromosome alignment onto the metaphase plate and its control by the checkpoint, and (iii) cytokinesis. We contributed significantly to the discovery of new players of the spindle assembly checkpoint: the kinesin Cenp-E and the kinase Mps1. More recently, we showed that the kinase Mps1 regulates the motility of Cenp-E in vitro. We also found that MPS1 kinase activity is potentiated by CDK1 during mitosis, which is essential to the mitotic checkpoint. Recently, we identified the small molecule UA62784 as a potent inhibitor of microtubule polymerization. We are now dissecting the regulation of microtubule dynamics in mitosis and during cellular motility, using a combination of in vitro reconstitution approaches, and quantitative cell biology.

 

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