Dr. F. Baklouti graduated from the "Ecole Normale Supérieure, Tunis, Tunisia", and received his Master Degree and Ph.D. in "Cellular and Molecular Biology" from the "Université Lyon 1, France", under the supervision of Dr. Jean Delaunay. His early research was focused on the molecular basis and mRNA metabolism of human globin gene mutations resulting in thalassemic hemoglobinopathies. He further contributed to the characterization of structural and functional defects associated with abnormal red cell morphologies, including protein 4.1R deficiencies in hereditary elliptocytosis. During his post-doc, he joined Dr. Edward Benz's laboratory at the "Department of Internal Medicine, School of Medicine, Yale University, New Haven, CT, USA", where he contributed to the cloning of the human 4.1R gene and to functional studies of 4.1R pre-mRNA alternative splicing regulation in the erythroid system. Dr. Baklouti is now a Research Director at the "Institut National de la Santé et de la Recherche Médicale (INSERM)", and a Principal Investigator at the "Centre de Génétique Moléculaire et Cellulaire, Univ. Lyon 1". He is also a member of the "American Society of Hematology", and a member of the Editorial Board of the International Scholarly Research Network (ISRN) Hematology.
Dr. Baklouti has been investigating protein 4.1R pre-mRNA splicing regulation at the cellular and molecular levels, both in normal and leukemic cells. He has also been studying some aspects of mRNA metabolism in erythroid and non erythroid cells, mostly related to inherited pathologic conditions. (see also: http://cgphimc.univ-lyon1.fr/spip.php?rubrique111)