From 1983 to 1987, I realized my master and thesis training at the CNRS 1174 Unit «Laboratory of Biochemistry of Connective tissue », Créteil (France). Then I moved on for a post-doctoral training in Caen (France) at the UPRES 2013« Laboratory of Biochemistry of Connective tissue » for 2 years when I got my INSERM position as a researcher in 1989.
In september 2000, I moved at the EA 3822 - INSERM U957 laboratory named « Pathophysiology of bone resorption and therapy of primary bone tumors » (Faculty of Medicine, Nantes, France) where I work as a research director at the head of a research team. I am also at the Head of the Experimental Therapy Unit, Faculty of Medicine, Nantes (France).
My team focused on new therapeutic approaches of bone primary tumors, namely osteosarcoma and Ewing's sarcoma by targeting both the tumor cells and cells from the bone micro-environment. Indeed, we have demonstrated that bone cells (osteoblasts and osteoclasts) are involved in a vicious cycle that takes place between resorbing cells (osteoclasts) and tumor cells. these results constitute the rationale for a clinical trial in France. Our research alsfocuses on cytokines of the TNF and its receptor superfamilies as potential therapeutic tools in these tumors.