Internat Ile de France 23Th 1992
Foreign Medical Graduate Examination in the Medical Sciences 1992
MD PARIS 7 1997
Assistant Professor november 97 to october 2000 Saint-Louis hospital Dermatology department Pr Dubertret.
Professeur of Dermatology (PU-PH) september 2002. C. Nicolle hospital Rouen, Dermatology department Pr Joly.
PhD PARIS 6 1996
HDR PARIS 5 2001
CR1 INSERM november 2000 to august 2002 INSERM 532 Saint Louis hospital
President of the "conseil scientifique de la Société Française de Dermatologie"
President of the "conseil d'orientation scientifique du programme national de recherche en Dermatologie"
Coordinator of the National program in Dermatology
Member of the board of the European Society for Dermatological Research
The skin constitutes a major barrier to the outside, which is constantly confronted to environmental aggressions of physical, chemical or microbial origin. The skin includes an immune system, able to develop an innate and adaptive immune response. In certain circumstances these responses can be exacerbated and then lead to immune-mediated skin disorders, such as skin adverse drug reactions and autoimmune diseases including systemic lupus erythematosus and autoimmune bullous diseases. The objective of our group was to understand the immunological mechanisms which sustain these immune dermatological diseases. A first project was aimed to understand the role of the T cells in drug- induced eruptions and to assess, the respective roles of drugs and viral reactivations on the T cell activation. A second project was focused on the role of TLRs on the development of the autoimmune B cell response in lupus erythematosus, which is characterized by the diversity of the autoantibody response. Thirdly we performed a biological and clinical study on the innovative treatment of pemphigus patients with anti-CD20 monoclonal antibody. These studies were based not only on murine experimental models, but also on an original cognitive biological research in humans during therapeutic trials evaluating innovative treatments.