Nicolas Degauque
  • E-mail :[email]
  • Phone : +33 2 40 08 46 89
  • Location : Nantes, France
Last update 2018-05-14 17:39:37.191

Nicolas Degauque PhD Transplantation Immunology

Course and current status

EDUCATION AND EMPLOYMENT

10/14 to Pres: CRTI INSERM1064 (Nantes, France). Position: Researcher CR1

10/10 to 09/14: CRTI INSERM1064 (Nantes, France). Position: Researcher CR2

01/08 to 10/10: INSERM643 (Nantes, France). Training: Senior Postdoctoral Fellow (Mentor Jean-Paul Soulillou)

02/05 to 12/07: BIDMC, Harvard Medical School (Boston, USA). Training: Postdoctoral Fellow (Mentor Terry B Strom)

10/01 to 12/04: INSERM437 (Nantes, France). Training: PhD (Mentor Jean-Paul Soulillou)

RESEARCH FUNDING (2012-Present, Selected from a total of 10 grant awards totalling €1,334,600)

Current

  1. 1.     VISICORT: Adverse Immune Signatures and their Prevention in Corneal Transplantation (WP leader, Co-investigator). Funding Body: European Commission (FP7). Direct Costs : 710k€, 04/14 – 03/19.
  2. 2.     CD8+CD28NEG T cells, a threat to transplantation (Principal Investigator/Coordinator). Funding Body: Labex IGODirect Costs :256k€, 2016-2019
  3. 3.     Define the endothelium damage induced by TEMRA CD8 T cells from kidney transplant recipients (Principal Investigator). Funding Body: CENTAUREDirect Costs : 50k€, 2016-2018
  4. 4.     Dynamic of CD8 T cell selection in blood and biopsy of patients with subclinical intragraft inflammatory infiltrates(Principal Investigator).Funding Body:CENTAUREDirect Costs : 50k€, 2015-2017

Completed

  1. 1.     Projets de recherche translationnelle sur des cohortes et des biotiques(Principal Investigator/Coordinator).Funding Body: ITMO Sant PubliqueDirect Costs : 30k€, 2013-2015
  2. Progreffe International Felllowship (Principal Investigator). Funding Body: CENTAUREDirect Costs : 96k€, 2012-2015
  3. Study of direct alloreactive CD8 T+ cells in the evolution of kidney graft (Principal Investigator). Funding Body: ESOTDirect Costs : 35k€, 2012-2015

HISTORY OF MENTORING AND SUPERVISION (Past/Current):

PhD Students: 3/2. MSc/MD Students: 8/1. Undergrad Students: 6/2. Senior Technicians/Research Associates/Project Managers: 2/2.

COMMERCIALISATION ACTIVITIES: Patents: 1.

KEY ACHIEVEMENTS AND HONOURS:

Mentor-Mentee Award (TTS) 2013; Post-doctoral Fellowship from TTS (Transplantation Society) 2008 -2010; Young Investigator Award (ATC) 2007. Peer Reviewer for >10 Scientific Journals. Invited Lectures (2006-Pres.): 10. Presentations at National/International Meeting as Presenting or Senior Author (2000-Pres.): 22 Oral and 37 Posters.

Scientific summary

My research is dealing with the study of  the involvement of CD8 T cells and B cells in transplantation immunology, especially to decipher the immunological mechanisms leading to late chronic transplantation rejection for kidney recipients.Thanks to a close collaboration with the clinical team, we are mainly studying the immune response using biological samples retrieved from transplanted patients.

We are also interested in the analysis of the TCRVb repertoire in various immunological settings.

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