1971-1980 Physiologie Comparée,. Pr. E. Coraboeuf Université Paris-sud Orsay.
- Assistant Professor, Université Paris Sud, 1974-1975.
- Attachée de Recherche CNRS, October 1976.
1981-1993 Physiologie Cellulaire Cardiaque U-241 INSERM. Dr. G. Vassort Orsay.
- Chargée de Recherche CNRS, October 1982.
- Directrice de Recherches 2d class CNRS, since October 1990.
1993-2006: Cardiologie Cellulaire et Moléculaire U-446 INSERM Université Paris-Sud Châtenay-Malabry. R. Fischmeister.
2006-present: Signalisation et Physiopathologie cardiaque U-769 INSERM Université Paris-Sud Châtenay-Malabry. R. Fischmeister.
- Directrice de Recherches first class CNRS since October 2003
Since 1996 : responsible of a Research team « Energy metabolism in cardiac and skeletal muscle”.
My main research field concerns energy fluxes in cardiac and skeletal muscle cells on a physiological basis starting from the subcellular compartments to the integrated animal models and human. We have been deeply involved in researching the role of the creatine kinase system in cellular energy transfer, and demonstrating intracellular compartmentation of energy fluxes through enzyme-enzyme interactions or direct energy crosstalk between organelles in cardiac and skeletal muscles. We have demonstrated the direct energetic interactions between mitochondria and other organelles like sarcoplasmic reticulum and myofilaments and their alterations in heart failure. We are studying alterations in energy metabolism in heart failure using functional biochemical and molecular approaches. We have shown a down-regulation of the transcriptional pathway of mitochondrial biogenesis in pathological cardiac and skeletal muscle cells. We are the studying signaling pathways involved in the control of muscle energy metabolism including AMPK, sirtuins, thyroid hormones etc... We investigate the relevance of metabolic therapy by resveratrol and exercise in heart failure.