denis angoulvant
  • E-mail :[email]
  • Phone : +33247474652
  • Location : Tours, France
Last update 2016-04-12 13:12:35.913

denis angoulvant Pr Denis Angoulvant, MD, PhD - Cardiology & Cardiovascular Physiology

Course and current status

Course

Clinical training at University Hospital of Lyon, France and Claude Bernard University Lyon 1, Lyon, France. MD obtained in 2002.

Research training at Inserm U886 (Pr Ovize) Lyon, France and Toronto General Hospital - University Health Network (Dr R Weisel and Dr R-K Li) 2003-2005, Toronto, Ontario, Canada. PhD obtained in 2008.

Albert Sezary award of the French National Academy of Medicine.

Research fellowship "Lavoisier" from the French ministry of foreign affairs

Research fellowship and PhD fellowship from the Fédération Française de Cardiologie.

Research fellowship from the Fondation pour la Recherche Médicale 2012.

Research grant from the fédération Française de Cardiologie 2012.

Research grant from the Agence de la Biomédecine 2013.

Research fellowship from the fédération Française de Cardiologie 2013.

Current position

Professor of cardiovascular medicine (Cardiac Intensive Care Unit & Interventional Cardiology) at Tours University Hospital, Hôpital Trousseau, and François Rabelais University, Tours, France.

Senior researcher at EA 4245 « Cellules Dendritiques, Immuno-Intervention Et Greffes » member of the MABimprove research group and University Hospital Federation "SUPORT"

Director of the department of Medical Pedagogy, Faculty of medicine - François Rabelais University, Tours, France.

Scientific summary

In basic science, my research interests focus on cardiac protection and cardiac regeneration. I am conducting preclinical studies investigating the cardioprotective effects of mesenchymal stem cells and their secretome at the time of reperfusion of acute myocardial infarction and heart graft transplantation. I am also working on regulation of inflammation and immune signalling for acute and chronic myocardial diseases : Damage Associated Molecular Patterns, TLR, stem cell mobilisation, cytokine activation, extracellular matrix remodeling, dendritic cells modulation, myocardial cell injuries.

I am collaborating with the MABImprove research group (http://mabimprove.univ-tours.fr/?lang=en) specialized in the development and evaluation of monoclonal antibodies for the treatment of numerous diseases including cardiovascular diseases.

Our research group is involved in the FHU "SUPORT" an Inter University Hospital collaboration aiming at improving solid organ graft survival.

In clinical research, I am the director of the cardiovascular intensive care & interventional cardiology research group of our university hospital.

Our group is actively recruiting patients in clinical studies on ischemic and pharmacologic post conditioning to prevent  acute myocardial reperfusion infarction. We are also participating in clinical trials and registries evaluating the procedural, short and long term clinical outcomes of coronary stent implantation. Because of our involvment in the MABImprove group we are actively recruiting patients in clinical trials evaluating Therapeutics Monoclonal Antibodies in cardiovascular diseases such as anti PCSK9 MABs. We are also members of the FACT (French Alliance for Clinical Trials) network.

Editorial activities :

Member of the editorial board of Archives of Cardiovascular Diseases

Member of the editorial board of the Journal of Molecular and Cellular Cardiology.

Medical and scientific societies :

Current President of the GRRC (Cardiovascular Research Branch of the French Society of Cardiology)

Current President of the regional association of the  Fédération Française de Cardiologie for the Loire Valley

H index : 20 (Web of Science)

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