Scientific topics
Keywords
denis angoulvant Pr Denis Angoulvant, MD, PhD - Cardiology & Cardiovascular Physiology
Course and current status
Course
Clinical training at University Hospital of Lyon, France and Claude Bernard University Lyon 1, Lyon, France. MD obtained in 2002.
Research training at Inserm U886 (Pr Ovize) Lyon, France and Toronto General Hospital - University Health Network (Dr R Weisel and Dr R-K Li) 2003-2005, Toronto, Ontario, Canada. PhD obtained in 2008.
Albert Sezary award of the French National Academy of Medicine.
Research fellowship "Lavoisier" from the French ministry of foreign affairs
Research fellowship and PhD fellowship from the Fédération Française de Cardiologie.
Research fellowship from the Fondation pour la Recherche Médicale.
Current position
Professor of cardiovascular medicine (intensive cardiac care unit & interventional cardiology) at University Hospital of Tours, Hôpital Trousseau, and François Rabelais University, Tours, France.
Senior researcher at EA 4245 « Cellules Dendritiques, Immuno-Intervention Et Greffes » member of the MABimprove research group
Faculty of medicine - François Rabelais University, Tours, France.
Scientific summary
In basic science, my research interests focus on cardiac protection and cardiac regeneration. I am conducting preclinical studies investigating the cardioprotective effects of mesenchymal stem cells and their secretome at the time of reperfusion of acute myocardial infarction and heart graft transplantation. I am also working on regulation of inflammation and immune signalling for acute and chronic myocardial diseases : Damage Associated Molecular Patterns, TLR, stem cell mobilisation, cytokine activation, extracellular matrix remodeling, dendritic cells modulation, myocardial cell injuries.
I am collaborating with the MABImprove research group (http://mabimprove.univ-tours.fr/?lang=en) specialized in the development and evaluation of monoclonal antibodies for the treatment of numerous diseases including cardiovascular diseases.
In clinical research, I am the director of the cardiovascular intensive care & interventional cardiology research group of our university hospital. I am the principal investigator of a clinical study evaluating myocardial microvascular disease in these patients: Myocardial Microvascular Disease in ESRD (MICROCARD) NCT01291771.
Our group is actively recruiting patients in clinical studies on ischemic and pharmacologic post conditioning to prevent acute myocardial reperfusion infarction. We are also participating in clinical trials and registries evaluating the procedural, short and long term clinical outcomes of coronary stent implantation. We are collaborating with reaserch groups and companies involved in monoclonal antibodies evaluation in cardiovascular diseases.
I am member of the editorial board of the Journal of Molecular and Cellular Cardiology.
I am vice president of the GRRC (Cardiovascular Research Branch of the French Society of Cardiology)
I am the President of the regional association of the Fédération Française de Cardiologie for the Loire Valley
H index : 15 (Google Scholar)
