CV Science

Michel Legraverend PhD Medicinal Chemist

Course and current status

Diplomas

-graduated from University of Paris-Sud, 91405 Orsay, France

-Thèse de 3ème cycle spécialité Biochimie (Orsay, février 1975.  (Professeur E. Lederer, ICSN, CNRS, Gif sur Yvette)

-Thèse d'Etat spécialité Sciences Physiques option Chimie (Dr E. Bisagni, Institut Curie, Laboratoire de Pharmacochimie, Orsay, novembre 1983).

HDR given with the PhD (Thèse d’Etat)

Post-doctoral experience

1977-1978, NIH, NCI, Bethesda, Maryland, USA, (Laboratory of Medicinal Chemistry and

Biology, Applied Pharmacology Section)

Laboratory

Conception, synthèse et vectorisation de biomolécules, UMR176 CNRS/Institut Curie, Institut Curie, Bât. 110, Centre universitaire, 91405 Orsay

Status

CR1 INSERM

Scientific summary

Research interests

Numerous new synthesis methodologies are developped which can be applied to heterocycles and more particularely to purines. These methodologies include regioselective functionalizations of the purine nucleus by metalation, Suzuki and Sonogashira cross-couplings, or by building purine derivatives from pyrimidine precursors. The synthesis of protein kinase targeted libraries has been the subject of many works which have led to the identification of several protein kinase inhibitors (CDK1, CDK2, CDK5, GSK3-b, CK1, Tyro3, Met).

Publications

70 articles in international Journals