NICOLAS RAMOZ Molecular Genetic and Epigenetic in neuropsychiatry

Course and current status

Education and Career

2009-Present: Senior Reseacher Associate (INSERM CRCN) in Molecular and Genetic Neuropsychiatry, INSERM UMR1266, Institute of Psychiatry and Neuroscience of Paris (previous Center of Psychiatry and Neuroscience), Pr Philip Gorwood's Team Genetics of addictive and psychiatric disorders, University René Descartes-Paris 5, PRES Sorbonne-Paris Cité, Sainte-Anne Hospital, Paris, France

2010: HDR-Principal Investigator Thesis in Molecular Genetics in Psychiatry, Faculty of Medicine, University René Descartes-Paris 5, Paris, France

2005-2008: Senior Reseacher Associate (INSERM CR1) in Molecular and Genetic Neuropsychiatry, INSERM U675, Head Pr Philip Gorwood, Phenotypic, developmental and genetic analysis of addictive behaviors, IFR2, Faculty of Medicine X Bichat, University of Denis Diderot-Paris 7, Paris, France

2001-2005: Post-doctoral fellow/Instructor in Molecular Genetic Psychiatry, Pr Joseph Buxbaum's Laboratory of Molecular Neuropsychiatry, Mount Sinai School of Medicine, MSSM, New York, NY, USA

2000-2001: Post-doctoral fellow in Human Molecular Genetics, Pr Gérard Orth Unit of Papillomavirus/INSERM U190, Pasteur Institute, Paris, France

1995-2000: Ph.D. Thesis in Molecular Biology and Human Genetics of vulnerability to HPV infection, Dr Michel Favre and Pr Gérard Orth Unit of Papillomavirus/INSERM U190, Pasteur Institute, University Denis Diderot-Paris 7, Paris, France

Scientific summary

My researches investigate the roles of human genetic and epigenetic factors involved in addictive disorders (including eating disorders, such as anorexia nervosa, and substance use disorders, like alcohol-dependence) and psychiatric disorders (schizoprhenia, major depression disorder, ADHD and autism). Taking into account of clinical and neurocognitive evaluations and biological samples (DNAs, RNAs, miRNAs and proteins) from patients, remitters, families and controls, I am search for biomarkers of the mental health. The goal of my researches is to decipher the neurobiological mechanisms involved in the psychiatric disorders, and to identify biomarkers to propose diagnostic and prognostic better and earlier.

I am a member of the Genome Wide Anorexia Nervosa international consortium (PIs C Bulik, D Collier, P Sullivan).

Expertises in genetics, molecular biology, epigenetics and pharmacogenetics in addictive and psychiatric disorders.

Publications more than 110 papers in peer journals and 20 chapters in books (Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa. Nat Genet. 2019 Aug;51(8):1207-1214. doi: 10.1038/s41588-019-0439-2)

Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa.