• E-mail :[email]
  • Phone : +33 1 57 27 67 57
  • Location : Paris, France
Last update 2014-01-10 10:51:00.876

Fabrizio Mammano PhD Virology

Course and current status

Current position:         

Director of Research at INSERM

Head, Virus Evolution and Pathogenesis group

INSERM U941, Hospital Saint Louis, Paris, FRANCE

 

Education:

M.Sc. Nov 1989, Faculty of Biology, University of Padua, Italy

Ph.D. Sept 1994, (Virology) University of Padua, Italy

HDR  Apr 2005, University Paris VII, France

 

Professional Experience:

2007-2010 Director of Research, Department of Virology, Institut Pasteur, Paris FRANCE

1999-2006 Staff Scientist, INSERM U552 Antiviral Research, Hosp. Bichat, Paris, FRANCE

1996-1998 Post-Doc, Department of Virology, Institut Pasteur, Paris FRANCE

1992-1996 PhD Student + Post-Doc, Harvard Medical School, Boston MA, USA

1990-1992 PhD Student, Institute of Oncology, University of Padua, Italy

Scientific summary

My research focuses on HIV (human immunodeficiency virus), with two main axes: virus replication and virus evolution.

HIV replication. I have studied different steps of the HIV replication cycle, in particular: the process of HIV entry into target cells and virus tropism, proviral DNA integration, virus particle assembly, incorporation of the envelope glycoproteins into virions, virus pseudotyping. At present, research in my group focuses on the transmission of HIV from cell-to-cell and on interference with super-infection.

HIV evolution. I have worked for several years on the development of HIV resistance to antiretrovirals targeting different steps of the virus replication cycle. The aim was to elucidate the parameters driving the selection of specific drug-resistance mutations in treated patients. Among these, the impact of drug-resistance on virus fitness was a major issue of my research. At present, I explore the impact of type-I interferon on HIV replication and the viral strategies that lead to virus escape from interferons, both in vitro and in treated patients.

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