Frédéric Causeret PhD Developmental Neurobiology

Course and current status

Since 2016: Inserm CR1 researcher in the team of Alessandra Pierani. Institut Jacques Monod - Paris, France. http://www.ijm.fr/en/research/research-groups/cortex-cerebral/

2012-2015: Inserm CR2 researcher in the team of Alessandra Pierani. Institut Jacques Monod - Paris, France.

2007-2011: Inserm Junior post-doctoral fellow in the team of Alessandra Pierani. Institut Jacques Monod - Paris, France.

2004-2007: EMBO post-doctoral fellow in the team of Margareta Nikolić. Imperial College London - London, UK.

2001-2004: PhD student under the direction of Evelyne Bloch-Gallego. Inserm U106 and Institut Cochin - Paris, France.

Scientific summary

I am interested in understanding the cellular and molecular mechanisms of brain development, especially neurogenesis, cell survival, neuronal migration and axon guidance. I use a wide range of approaches including mouse genetics, histology, neuronal culture, biochemistry and molecular biology to better understand the extracellular and intracellular signalling pathways involved in these processes.

Past and recent findings:

- Identification of Kremen1 as a novel dependence receptor

- Role of dbx1-expressing cells in forebrain survival and patterning

- Function of Pak1 during cortical migration and the establishment of neuronal polarity

- Identification of Neurabin-I as a new target of Cdk5 during neuronal morphogenesis

- Involvement of Rac, Rho, Cdc42 and their effectors in axon growth and neuronal migration

- Role of Netrin-1 and Slits in the migration and survival of precerebellar neurones

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