December 5 1963
Research Director (DR1) CNRS
Ph.D (1988) and Capacity to Direct Research Programs (HDR, 1996), Nice Sophia Antipolis University
PRESENT AND PAST POSITIONS
INSERM U1065/Mediterranean Center for Molecular Medicine (C3M), Nice, France
. Since 2007: Group Leader Team “Molecular and Cellular Pathophysiology of Obesity and Diabetes”. Study of i) Mechanism of insulin resistance in obesity and type 2 diabetes: role of adipose tissue inflammation and hypoxia and ii) adipose tissue dysfunction and risk of cancers and Scientific deputy director of the research center.
INSERM U568, Nice, France
2003- 2007. Group Leader. Study of Insulin-dependent and independent pathways involved in glucose transport and of IRS serine phosphorylation and insulin resistance.
1999-2003. Senior scientist CR1. Study of the molecular mechanisms in insulin resistance
INSERM U145, Nice, France
1993-1998. Senior scientist CR1. Insulin signaling pathways involved in glucose transport.
1989-1992. Junior scientist CR2. Structure function of the glucose transporters
1984-1988. Ph.D Student. Role of PKC and cAMP dependent kinase in the modulation of the insulin signaling and metabolic effects
Main research topics :
Our team is part of the Metabolic diseases department at Mediterranean Center of Molecular Medicine with four other teams involved in signalling and molecular mechanisms controlling metabolic diseases and also the relationship between metabolic diseases and cancer. Our team has a long-standing experience in the study of the mechanisms of insulin resistance and adipose tissue dysfunction in obesity and type 2 diabetes. Our present work aims at deciphering the cellular and molecular mechanisms involved in insulin resistance induced by adipose tissue stresses such as inflammation, hypoxia and cellular senescence. We also decipher the pathophysiological mechanisms responsible for the association between obesity/diabetes and the occurrence of cancer. Physiological, molecular techniques and animal experimenting are currently used in our team.