I am Senior Researcher at the Institut national de la santé et de la recherche médicale (INSERM) and head the Pierre Louis Institute of Epidemiology and Public Health Unit UMR-S 1136 at INSERM and Université Pierre et Marie Curie (UPMC) in Paris, France. I am the Principal Investigator of the French Hospital Database on HIV (FHDH ANRS CO4) and I am a member of the executive board for EUROCOORD (NoE FP7), a consortium of European HIV cohorts, and I head its council of partners and for ART-CC a consortium of HIV cohorts from Europe and North America. I am also Head of one of the monitoring and statistical data analysis centres for ANRS trials and cohorts. My main fields of competence include biostatistics, epidemiology, including pharmacoepidemiology, clinical trials and modelling applied to HIV infection, haemophilia, drugs and viral safety of blood transfusion.
I have extensively studied incubation time for AIDS, prevalence of HIV infection, the timing of mother-to-child HIV-1 transmission, the effects of antiretroviral therapy in HIV-infected patients, resistance to ARVs and AIDS and severe non-AIDS morbidity in HIV patients, in particular cancers and myocardial infarction.
Besides research activities, I am deeply involved as an expert for the Ministry of Health; AFSSAPS, the French Drug Agency; HAS, the French National Authority for Health; ANSES, the French Agency for Food, Environmental and Occupational Health and Safety; and in scientific evaluation (AERES, ANR, ANRS, INRA, INSERM, IRD, NIH, …). For instance, I serve as a member of the French working group on management of HIV infected patients and several ANRS (Agence Nationale de la Recherche sur le SIDA et les hépatites virales) boards and I am the president of the Epidemiology and Public Health INSERM Scientific Commission.
I head the Doctoral School Pierre Louis of Public Health (ED 393).