CV Science

Anne-Louise Leutenegger Ph.D. Biostatistics - Statistical Genetics

Course and current status

Research Scientist (Chargée de Recherche Hors Classe) at Inserm NeuroDiderot (U1141), Paris.
StatGen: statistical method developments for genomics.

Past Positions

2009-2018: Research Scientist, Genetic Variation and Human Diseases Lab (U946), Inserm, Paris. Contribution of population genetics to the study of human diseases: statistical developments for mapping disease genes in isolated and consanguineous populations.

2006-2009: Research Scientist, Genetic Epidemiology and Human Population Structure Lab (U535), Inserm, Villejuif. Genetic determinism of human diseases in consanguineous populations.

2003-2006: Post-doc, Central Nervous System Disorders Lab (U679), Inserm, Paris. Mapping genes involved in neurodegenerative disorders using consanguineous populations.

1998-2001: Research assistant, dept. Biostatistics and Medicine, Univ of Washington, Seattle, USA. Segregation analysis of dyslexia, Linkage analysis of sib-pairs affected with autism.

1997-1998: Teaching assistant, dept. of Statistics, Biostatistics & Center for Quantitative Science, Univ of Washington, Seattle, USA.

Education

2024 : HDR Genomics & Human diseases - Univ Paris Cité (FR)

2003: Ph.D. in Biostatistics, emphasis in Statistical Genetics - jointly between Univ of Washington & Univ Paris Sud. Co-advisors: Elizabeth Thompson (UW), Françoise Clerget-Darpoux (Inserm). Title: Estimation of random genome sharing; consequences for linkage detection

1998: M.S. in Biostatistics - Univ of Washington (Seattle, USA)

1997: Paris School of Statistics, Economics & Finance - ENSAE (FR)

1995: Maîtrise in Applied Mathematics & Social Sciences - Univ Paris Dauphine (FR)

Boards

2020-present: Scientific advisory board of Inserm workshops

2017-2021: Scientific advisory board of Inserm

2012-2016: Evaluation/recruitment committees of Inserm: Public Health (CSS9), Research Support (CAR)

2011-present: Editorial board of Genetic Epidemiology, https://onlinelibrary.wiley.com/journal/10982272

Awards

Thesis award from the French Biometrics Society (2004)

Scientific summary

My research interests lie at the interface of biostatistics, genetic epidemiology and population genetics. The aim of my research is to identify the genetic basis of human trait/disease by using statistical methods and analysing genomic data from families or populations. My work is mainly focused on neuroscience applications.

My methodological projects are structured around 2 main axes: the contribution of population genetics to medical genetics, and a more recent axis on the study of large-scale data, typically data from general population or medical biobanks (several hundred thousand participants).

In terms of applications, my work has helped to identify and better understand the genetic basis of several diseases, such as neurodevelopmental disorders (autism, microcephalic syndrome, anencephaly), neurodegenerative diseases (Parkinson's disease, spino-cerebellar degenerations, amyotrophic lateral sclerosis) and, more recently, neurovascular diseases (CADASIL, fetal intracerebral haemorrhage).