Fabrice Wendling Signal Processing & Computational Modeling in Epilepsy

Course and current status


 2008 - : INSERM Senior Research Scientist (“Directeur de recherche”).

1998 - 2008: INSERM Junior Research Scientist (“Chargé de recherche”)

1996 - 1998  Assitant professor, University of Rennes 1

Since 2012: Head of the team SESAME: “Epileptogenic systems: signals & models”, LTSI - Inserm U1099, Rennes, France

2002-12: Head of the team EPIC: “Dynamics of neuronal systems in Epilepsy”, LTSI - Inserm U642, Rennes, France


- Habilitation to supervise research, University of Rennes 1, Rennes, France (2003). Title: “Analysis and modeling of EEG signals. Contribution to the study of the pathophysiology of human partial epilepsies”

- PhD (Signal processing and Telecommunication), University of Rennes 1, Rennes, France (1996)

- Master of Science (Bioengineering), Georgia Institute of Technology, Atlanta, USA (1991)

- Engineer diploma (Biomedical Eng.), University of Technology of Compiègne, Compiègne, France (1989)

Scientific summary

Fabrice Wendling (FW) has been working on epilepsy for 20 years in close collaboration with clinicians. His work is devoted to brain signals analysis and computational modeling of neuronal systems. FW has developed specific methods to analyse EEG signals (scalp and intracerebral), recorded during ictal (seizures) and interictal (outside seizures) periods. He has also developed computational models of brain electrical activity generation (at cellular and population level). Some models are specifically adapted to the cellular organization of structures predominantly involved in temporal lobe epilepsy (like hippocampus and entorhinal cortex). They are used worldwide (see http://www.scholarpedia.org/article/Models_of_epilepsy) to interpret local and global field potentials recorded from the epileptic brain during interictal and ictal periods. FW has authored/co-authored about 100 papers in peer-reviewed journals and 4 patents. Journals can be divided in two categories according to their scope, either “methodological” (IEEE TBME, IEEE TITB, Annals Biomed. Eng., PTRSA) or “clinical” (Ann. Neuol., Brain, Clin. Neurophysiol., J. Neurophysiol., J. Physiol.).

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