Marc Daëron
  • E-mail :[email]
  • Phone : +33-1-4568-8642
  • Location : Paris, France
Last update 2011-04-05 17:35:47.979

Marc Daëron MD, PhD

Course and current status

1972-1974: Full-time internship, FRM and LNCC scholarships. Laboratoire d'Immunopathologie et d'Immunologie Expérimentale, Inserm U. 23, Dir. Dr G.-A. Voisin, Hôpital Saint-Antoine, Paris.

1974-1976: Post-doctoral Fellow: Department of Experimental Surgery, Dir. Dr J. Gordon, McGill University, Montréal, Québec, Canada

1976-1980: Attaché de Recherche at Inserm, Laboratoire d'Immunopathologie et d'Immunologie Expérimentale, Inserm U. 23, Dir. Dr G.-A. Voisin, Hôpital Saint-Antoine, Paris.

1980-1982: Chargé de Recherche at Inserm. Post doctoral fellow, Department of Basic Immunology, Dir. Dr K. Ishizaka, The Johns Hopkins University School of Medicine Baltimore, Maryland, USA ; Recipient of Philippe Foundation and Lillia Babbit Hyde Foundation bursaries.

1982-1989: Chargé de Recherche de 1è classe at Inserm, Laboratoire d'Immunologie Cellulaire et Clinique, Inserm U. 255, Dir. Dr W. H. Fridman, IRSC, Villejuif (1982-83), Institut Curie, Paris (1983-89).

1989-1996: Directeur de Recherche de 2è classe at Inserm, Laboratoire d'Immunologie Cellulaire et Clinique, Inserm U. 255, Dir. Dr W. H. Fridman, Institut Curie, Paris ; Visiting Scientist (September 1993) Laboratory of Molecular Allergy and Immunology, Dir. Dr J.-P. Kinet, National Institutes of Health, Rockville, Maryland, USA.

1996-2003: Directeur de Recherche de 1è classe at Inserm, Laboratoire d'Immunologie Cellulaire et Clinique, Inserm U. 255, Dir. Pr W. H. Fridman, Institut Curie, Paris (1996-2001), Institut Biomédical des Cordeliers, Paris (2001-2003). Visiting Scientist (July 2002) Laboratory of Molecular Genetics and Immunology, Dir. Dr. J. V. Ravetch, The Rockefeller University, New York, USA.

Since 2003: Directeur de l'Unité de Recherche Allergologie Moléculaire & Cellulaire, Institut Pasteur, Paris. Since 2006: Directeur de l’Unité Inserm 760 at Institut Pasteur, Paris. 2006-2010: Directeur du Département d’Immunologie de l’Institut Pasteur, Paris Since 2008: Chef de Laboratoire à l’Institut Pasteur, Paris

Since 2010: Directeur de Recherche de Classe Exceptionnelle at Inserm

Scientific summary

The activation of hematopoietic cells is positively and negatively controlled by membrane receptors. Among these are receptors for the Fc portion of antibodies (FcRs). Antibodies can both activate and inhibit cell activation when engaging activating and/or inhibitory FcRs. Activating FcRs contain or are associated with subunits which contain Immunoreceptor Tyrosine-based Activation Motifs (ITAMs). Inhibitory FcRs contain an Immunoreceptor Tyrosine-based Inhibition Motif (ITIM). Our unit studies 1) signals generated by activating and by inhibitory FcRs and their integration, 2) the roles of the various FcRs and the cells by which they are expressed in murine models of inflammatory diseases, particularly in mice the endogenous FcRs of which have been replaced by human FcRs, and 3) FcR-dependent activation and negative regulation in cells from normal donors and allergic patients.

Image d’exemple