-1979/1985: Medical school, Université Paris V, CHU Paris-Ouest.
-1985/1987: Intern in general medicine, Université Paris V.
-1988: Thesis of Medicine, Université Paris V.
-1983/1984: Licence de biologie cellulaire, Université Paris VI.
-1984/1985: Maîtrise de biologie cellulaire, Université Paris VI
(equivalent to a Bachelors degree),
Options: Molecular biology, Molecular biophysics, Membrane biophysics
-1985/1986: DEA de Génétique (Prof. Piotr Slonimsky), Université Paris VI
(equivalent to a Masters degree).
-1987: Course of General Virology at the Pasteur Institute.
-2000: HDR, Université Paul Sabatier, Toulouse
- 1982: Laboratory of Dr. Jacques Leibowitch, Hôpital Raymond Poincaré, 92380 Garches.
Subject: Study of circulating immunoglobulins in patients with Berger's nephropathy.
- 1984: Laboratory of Prof. A.D. Strosberg, Institut Jacques Monod, Paris.
Subject: Biochemical characterisation of the human ß2 adrenergic receptor.
- 1986: Laboratory of Prof. F. Jacob, group of Dr. J. F. Nicolas, Institut Pasteur, Paris.
Subject: Optimisation of retroviral vector usage for transfecting tissue culture cells.
- 02/88 - 02/91: Laboratory of Prof. M.B.A. Oldstone, Scripps Clinic, La Jolla, California.
Subject: Role of MHC class I antigens in presenting LCMV epitopes to CTLs.
- 03/91 - 09/92: Laboratory of Dr. J. Williams, ICRF Clare Hall Laboratories, England.
Subject: Development of an enhancer trap in Dictyostelium discoideum.
- 10/92 - 03/99: Laboratory of Immunogenetics, The Babraham Institute, Cambridge, UK. Subjects:
1) Characterisation of functional interactions between alleles of MHC class I molecules and TAP transporters.
2) Analysis of the molecular mechanisms controlling the down-regulation of MHC class I expression in nervous tissues.
- 04/99 - 08/05 : Group leader of Neuro-Immuno-Genetics research team.
Institut Claude de Préval, CHU Purpan, Toulouse.
Evolution of MHC class I molecules
Expression and functionnal role of MHC molecules in the CNS.
Trogocytosis: How does it work, and why ?
How does the physical state of biological membranes relate to their functions ?
- 09/05- today: Group leader of Neuro-Immuno-Genetics research team. IPBS, Toulouse.
1) Does MeCP2 have immunomodulatory roles ?
2) Trogocytosis: How does it work, and why ? And how can we exploit it ?
3) How does the physical state of biological membranes relate to their functions ? 4) The role of recessive mutations and inbreeding in processes of speciation.
Interested in MHC class I molecules and immunogenetics for many years, in particular regarding rat MHC class I molecules. Other interests include neuroimmunology, Rett syndrome and MeCP2, trogocytosis, membrane biophysics, and more recently, evolution and speciation. I am also a very dedicated advocate of open access publishing, and hope that it will it will soon become the norm. I am also trying to contribute to the setting up of unique scientific author identification (or SLIP, for Scientist LIcense Plate), in particular via the recent ORCID initiative.