Jean-Noel Freund
  • E-mail :[email]
  • Phone : +33 3 88 27 77 27 (std)
  • Location : INSERM UMR_S1113; Strasbourg, France
Last update 2017-09-18 12:03:55.131

Jean-Noel Freund PhD, Molecular and Cellular Biology

Course and current status

Director of the Unit UMR_S1113 of INSERM / University of Strasbourg: Developmental and Cell Stress Signaling in Digestive and Urological Cancer

Leader of Team 1:  Intestinal Identity: from Stem Cells to Pathology

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PhD in Cellular and Molecular Biology, University Louis Pasteur, Strasbourg, France (1986): "The rudimentary gene of Drosophila melanogaster: structure, expression and function" (LGME Inserm U184, supervisor: Prof P Chambon).   

Scientific summary

The UMR_S1113 is composed of 3 teams.

> Team 1 (Leader JN Freund): Intestinal identity: from stem cells to pathology.

> Team 2 (Leader C Gaiddon): Molecular mechanism of the stress response and pathologies.

> Team 3 (Leader T Massfelder): Cell signaling and communicaiton in kidney and prostate cancer.

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Team 1.

Our work explores the molecular mechanisms involved in embryonic development and tissue homeostasis, and their alteration in pathologies.

We focus on cancer and inflammatory diseases in the digestive tract and hematopoietic system.

Studies concentrate on the homeotic transcription factor CDX2 and its downstream targets and partners such as the atypical cadherin MUCDHL/CDHR5 and the DNA repair complex KU70/80.

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