• E-mail :[email]
  • Phone : +33 4 26 55 67 48
  • Location : Lyon, France
Last update 2015-02-12 14:33:35.081

Julien MARIE PhD in immunology,

Course and current status

Current position

Since 2013   Directeur de recherche DR2 Inserm (senior permanant researcher)

Since 2013    Director of the Inserm Helmholtz lab, Lyon France

Since 2013   In charge of the Immunology Virology and cancer program of the master  of oncology of  University Lyon 1

Since 2009   Head of the TGF-beta and Immune Evasion Lab,  Immunology Virology and Inflammation Dpt, C R C L,  Lyon france

Education and academic positions

1999-2002: PhD in immunology, Topic: regulation of inflammatory responses by Measles virus proteins). Ecole Normale Supérieure de Lyon

2003-2005: PostDoc Follow, Topic: regulation of T cell responses. Prof A. RUDENSKY, Univ of Washington, Seattle USA, Human Frontier Science Program Fellow

2005: Chargé de  recherche Inserm ( unior permanant researcher)

2006-2009: Head of TGF-beta and Immune evasion lab, INSERM 758, Lyon

Scientific summary

My investigations are focused on the  effects of Transforming Growth Factor beta ( TGF-ß) on T lymphocyte biology and their consequences on autoimmune diseases and cancer developpment. Our works established T cells as the main target of cells of TGF-beta regulatory effects (Immunity 2006), and revealed TGF-ß has a master cytokine for Foxp3 regulatory T cell and NKT cell biology ( J.exp.Med 2005 and 2009). Using  different approaches, ranging from in vivo to gene regulation  levels,  we demonstrated that TGF-beta control the developpment and functions of key T cells subsets including NKT cells ( J. Exp. Med. 2009), TFH cells ( J. Clin. Invest. 2014), CD8 Effector and memory cells ( Immunity 2012, Nature Com. 2014) with  consequences on autoimmune disease  and cancer developpment.

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