LOREDANA SAVEANU
  • E-mail :[email]
  • Phone : +33 685680614
  • Location : PARIS, France
Last update 2018-01-04 19:03:40.705

LOREDANA SAVEANU Loredana Saveanu, MD, PhD Immunology

Course and current status

Charge de Recherche 1 ere classe (CR1) INSERM since 2005

ATIP-AVENIR team leader from 2015

Present adress:

INSERM U1149,

Hopital Bichat

 X Bichat Medical University, 5th floor

16 rue H Huchard

75018 PARIS

tel 0686604408

mail: loredana.saveanu@inserm.fr

Education:

1990             Bachelor’s degree, Biology and Chemistry College “D-na Stanca”, Satu-Mare, Romania

1996             MD, Faculty of Medicine and Pharmacy, Cluj Napoca, Romania

2004             PhD, Babes-Bolyai University, Romania. Host laboratory: Inserm U580/U25

2008             Habilitation à Diriger les Recherches, Université René Descartes Paris V

Scientific summary

Antigen processing and presentation by class I major histocompatibility complex (MHC-I) are fundamental for the acquired immune response and most of my research projects gravitated around the underlying molecular mechanisms of these processes. All nucleate cells of the body express MHC-I molecules. MHC-I binds short antigenic peptides to expose them at the cell surface in a configuration recognized specifically by the T cell receptor (TCR) of CD8+ T cells. The interaction between MHC-I loaded with antigenic peptides and the TCR is a crucial step for the immune defense against intracellular pathogens, viruses and tumors. My research activity started in 2000 and the results I obtained shed light on the function of the transporter associated with antigen presentation (TAP) and allowed the identification of two enzymes essential for the final processing of antigenic peptides before MHC-I loading: Endoplasmic Reticulum Aminopeptidase (ERAP) in the ER and Insulin responsive AminoPeptidase (IRAP) in endosomes. We demonstrated thus the existence of two pathways for antigen processing in cross-presentation (MHC-I presentation of endocytosed antigens).

More recently, our interest slightly shifted from the field of antigen presentation to the cellular biology mechanisms involved in the inflammatory response. Our team has recently demonstrated that IRAP protein has a dual function: beyond its enzymatic activity important for antigen processing during cross-presentation, IRAP has a structural role in the formation and stability of cell-specific storage endosomes. This has important consequences on the function of proteins that are cargos of IRAP vesicles. Thus, in dendritic cells, TLR9 traffics via IRAP endosomes and in the absence of IRAP, TLR9 activation is exacerbated. We are currently searching for new cargos of cell-specific storage endosomes described by IRAP in immune cells (DCs, T cells, B cells) and the implication of these endosomes in the regulation of the immune response.

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