• E-mail :[email]
  • Phone : +33 1 44 49 56 33
  • Location : PARIS, France
Last update 2011-05-20 13:57:46.988

LOREDANA SAVEANU Loredana Saveanu, MD, PhD Immunology

Course and current status

Charge de Recherche 1 ere classe (CR1) INSERM since 2005

Present adress:

INSERM U1013,

Hopital Necker, batiment Sevres, 5e etage,

149 rue de Sevres, 75015 Paris

Tel: 01 44 49 53 66

mail: loredana.saveanu@inserm.fr

Education:

1990             Bachelor’s degree, Biology and Chemistry College “D-na Stanca”, Satu-Mare, Romania

1996             MD, Faculty of Medicine and Pharmacy, Cluj Napoca, Romania

2004             PhD, Babes-Bolyai University, Romania. Host laboratory: Inserm U580/U25

2008             Habilitation à Diriger les Recherches, Université René Descartes Paris V

Scientific summary

Antigen processing and presentation by class I major histocompatibility complex (MHC-I) are fundamental for the acquired immune response and most of my research projects gravitated around the underlying molecular mechanisms of these processes. All nucleate cells of the body express MHC-I molecules. MHC-I binds short antigenic peptides to expose them at the cell surface in a configuration recognized specifically by the T cell receptor (TCR) of CD8+ T cells. The interaction between MHC-I loaded with antigenic peptides and the TCR is a crucial step for the immune defense against intracellular pathogens, viruses and tumors. My research activity started in 2000 and the results I obtained shed light on the function of the transporter associated with antigen presentation (TAP) and allowed the identification of two enzymes essential for the final processing of antigenic peptides before MHC-I loading: Endoplasmic Reticulum Aminopeptidase (ERAP) in the ER and Insulin responsive AminoPeptidase (IRAP) in endosomes. These latest findings indicated the existence of two pathways for antigen processing in cross-presentation (MHC-I presentation of endocytosed antigens) and their exploration is the main subject of my present work and projects.

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