• E-mail :[email]
  • Phone : 0169863043
  • Location : Orsay, France
Last update 2011-09-01 11:02:20.732

Alain MAUVIEL PhD, DR1 INSERM, Group Leader @ Institut Curie - alain.mauviel@curie.fr

Course and current status

01/2010-present, Group Leader, Team “TGF-beta and Oncogenesis“. Institut Curie, INSERM U1021/CNRS UMR3347

01/2005-2009, Head, INSERM U697: Molecular Bases of Skin Homeostasis, Paris, France

01/2004-present 1st class Research Director (DR1), INSERM

01/99 Research Director (DR2) INSERM, France – Adjunct Associate Professor, Dept of Dermatology and Cutaneous Biology, Jefferson Medical College, Philadelphia, PA

07/96-10/98 Associate Professor, Dept of Dermatology and Cutaneous Biology, Jefferson Medical College, Philadelphia, PA

07/94-06/96 Assistant Professor, Dept of Dermatology and Cutaneous Biology, Jefferson Medical College, Philadelphia, PA

07/93-06/94 Research Assistant Professor, Dept of Dermatology, Jefferson Medical College, Philadelphia, PA

10/93 Leave of absence from CNRS

03/93 Promotion to CR1 position, CNRS

01/92-06/93 Visiting Research Assistant Professor, Dept of Dermatology, Jefferson Medical College, Philadelphia, PA

01/91-12/91 Visiting Scientist, Dept of Dermatology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA

10/89 Tenured junior research scientist (CR2), CNRS, France

Scientific summary

Representative Publications (since 2000)

  1. Verrecchia, F., Pessah, M., Atfi, A., and Mauviel, A. TNF-a Inhibits TGF-b/Smad Signaling in Dermal Fibroblasts via Induction of AP-1/c-Jun. J. Biol. Chem. 2000, 275:30226-30231
  2. Kouba, D.J., Nakano, H., Nishiyama, T., Kang, J., Uitto, J., and Mauviel, A. Cell-Type Specific Role of the NF-kB-Inducing Kinase in NF-kB Activation by Tumor Necrosis Factor-a. J. Biol. Chem. 2001, 276:6214-6224
  3. Verrecchia, F., Tacheau, C., Schorpp-Kistner, M., Angel, P., and Mauviel, A. Induction of the AP-1 Members c-Jun and JunB by TGF-b/Smad Suppresses Early Smad-Driven Gene Activation. Oncogene, 2001, 20:2205-2211
  4. Verrecchia, F. Rossert, J., and Mauviel, A. Targeting Sp1 downregulates extracellular matrix gene expression in vitro and in vivo. Implications for gene therapy of fibrotic disorders. J. Invest. Dermatol. 2001, 116:755-763
  5. Verrecchia, F., Chu, M.-L., and Mauviel, A. Identification of novel TGF-b/Smad gene targets in dermal fibroblasts using a combined cDNA microarray/promoter transactivation approach. J. Biol. Chem., 2001, 276 :17058-17062
  6. Verrecchia, F., Vindevoghel, L., Lechleider, R.J., Uitto, J., Roberts, A.B., and Mauviel, A. Smad 3/AP-1 Interactions Control Transcriptional Responses to TGF-b in a Promoter Specific Manner. Oncogene, 2001, 20:3332-3340
  7. Ferrigno, O., Lallemand, F., Verrecchia, F., L’Hoste, S., Camonis, J., Atfi, A., and Mauviel, A. Yes-Associated Protein (YAP65) Interacts with Smad7 and Potentiates its Inhibitory Activity Against TGF-b/Smad Signaling. Oncogene, 2002, 21:4879-4884
  8. Verrecchia, F. and Mauviel, A. TGF-b Signaling through the Smad Pathway: Role in Extracellular Matrix Gene Expression and Regulation. J. Invest. Dermatol. 2002, 118:211-215 (review)
  9. Verrecchia, F., Wagner, E.F., and Mauviel, A. Distinct Involvement of the Jun-N-Terminal Kinase and NF-kB Pathways in the Repression of the Human COL1A2 Gene by TNF-a. EMBO Reports, 2002, 3:1069-1074
  10. Verrecchia, F., Tacheau, C., Wagner, E.F., and Mauviel, A. A Central Role for Jun-N-Terminal Kinase Activity in Mediating the Antagonistic Activity of Pro-inflammatory Cytokines Against Transforming Growth Factor-b-Induced Smad3/4 Signaling. J. Biol. Chem., 2003, 278:1585-1593
  11. Javelaud, D., Laboureau, J., Gabison, E., Verrecchia, F., and Mauviel, A. Disruption of Basal Jun-N-Terminal Kinase (JNK) Activity Differentially Affects Key Fibroblasts Functions Important for Wound Healing. J. Biol. Chem. 2003, 278:24624-24628
  12. Pendaries, V., Verrecchia, F., Michel, S., and Mauviel, A. Retinoic Acid Receptors Interfere with the TGF-b/Smad Signaling Pathway in a Ligand-Specific Manner. Oncogene, 2003, 22:8212-8220
  13. Schiller, M., Verrecchia, F. and Mauviel, A. Cyclic Adenosine 3’,5’-Monophosphate-Elevating Agents Inhibit Transforming Growth Factor-b-Induced SMAD3/4-Dependent Transcription Via a PKA-Dependent Mechanism. Oncogene, 2003, 22:8881-8890
  14. Verrecchia, F., and Mauviel, A. Control of type I collagen gene expression by TGF-b, interferences with pro-inflammatory cytokines. Cell. Signal., 2004, 16:873-880 (review)
  15. Dennler, S., Pendaries, V., Costas, M., Mauviel, A., and Verrecchia, F. The steroid receptor coactivator-1 (SRC-1) potentiates TGF-ß/Smad signaling.  Oncogene, 2005, 24:36-45
  16. Javelaud, D. and Mauviel, A. Crosstalk mechanisms between the mitogen-activated protein kinase (MAPK) pathways and Smad signaling downstream of TGF-b: implications for carcinogenesis. Oncogene, 2005, 24 :5742-5750 (review)
  17. Javelaud, D., Delmas, V., Moller, M., Sextius, P., André, J., Menashi, S., Larue, L., and Mauviel, A. Stable overexpression Smad7 in human melanoma cells inhibits their tumorigenicity in vitro and in vivo. Oncogene, 2005, 24: 7624-7629
  18. Schiller, M., Böhm, M., Dennler, S., Ehrchen, J., and Mauviel, A. Mitogen and Stress-Activated Protein Kinase 1 (MSK1) is Critical for Interleukin-1-Induced, CREB-Mediated, c-fos Gene Expression in Keratinocytes. Oncogene, 2006, 25:4449-4457
  19. Javelaud D., and Mauviel, A. Interplay between Smad and MAP kinase signalling pathways. In “Smad signal transduction”. Springer, C.H. Heldin and P. ten Dijke Editors. 2006, pp. 317-334
  20. Javelaud, D.*, Mohammad, K.S.*, McKenna, C.R., Fournier, P., Luciani, F., Niewolna, M., André, J., Delmas, V., Larue, L., Guise, T.A., and Mauviel, A. Stable overexpression of Smad7 in human melanoma cells impairs bone metastasis. Cancer Res., 2007, 67:2317-2324, *equal contributions
  21. Dennler, S., André, J., Alexaki, I., Li, A., Magnaldo, T., ten Dijke, P., Wang, X.-J., Verrecchia, F., and Mauviel, A. Activation of Sonic hedgehog mediators by TGF-b: Smad3/4-dependent induction of Gli2 and Gli1 expression in vitro and in vivo. Cancer Res. 2007, 67:6981-6986
  22. Alexaki, V.-I., Javelaud, D., and Mauviel, A. JNK supports survival in melanoma cells by controlling cell cycle arrest and apoptosis. Pigment Cell and Melanoma Res., 2008, 21:429-438
  23. Dennler, S., Andre, J., Verrecchia, F., and Mauviel, A. Cloning of the human GLI2 promoter – Transcriptional regulation by TGF-b via SMAD3/b-catenin interactions. J. Biol. Chem., 2009, 284:31523-31531.
  24. Schiller, M.*, Dennler, S., Anderegg, U., Kokot, A., Simon, J.C., Luger, T.A, Mauviel, A.*, and Bohm, M. Increased cAMP levels modulate Transforming Growth Factor-b (TGF-b)/SMAD-induced expression of extracellular matrix components and other key fibroblast effector functions. J. Biol. Chem., 2010, 285:409-421. *: co-senior authors.
  25. Alexaki, V.I.*, Javelaud, D.*, Van Kempen, L., Mohammad, K.S., Dennler, S., Luciani, F., Hoek, K., Juarez, P., Goydos, J.S., Fournier, P.J., Sibon, C., Bertolotto, C., Verrecchia, F., Saule, S., Delmas, V., Ballotti, R., Larue, L., Saiag, P., Guise, T.A., and Mauviel, A. GLI2-mediated melanoma invasion and metastasis. J. Natl. Cancer Inst., 2010, 102: 1148-1159. *: equal contributions
  26. Mohammad, K.S., Javelaud, D., Fournier, P.G.J., Niewolna, M., McKenna, C.R., Peng, X.H., Dunn, L.K., Mauviel, A.,* and Guise, T.A.*. Transforming Growth Factor-β Receptor I Kinase Inhibitor SD-208 Reduces the Development and Progression of Melanoma Bone Metastases. Cancer Res. 2011, 71:175-184. *: co-senior authors
  27. Javelaud, D., Van Kempen, L., Alexaki, V.I., Le Scolan, E., Luo, K., and Mauviel, A. Association of high c-Ski/SnoN expression and efficient TGF-b/SMAD signaling in human melanoma cells, Mol. Cancer 2011, 10:2
  28. Javelaud, D., Alexaki, V.I., Dennler, S., Mohammad, K.S.,Guise, T.A., and Mauviel, A. The TGF-eta/SMAD/GLI2 axis in tumor progression and metastasis. Cancer Res. 2011, 71:5606-5610 (Review)
  29. Javelaud, D., Alexaki, V.I, Pierrat, M.-J., Hoek, K.S., Dennler, S., Van Kempen, L., Bertolotto, C., Ballotti, R., Delmas, V., and Mauviel. A. GLI2 and M-MITF Control Exclusive Gene Expression Programs and Inversely Control Invasion in Melanoma Cells. Pigment Cell Melanoma Res., in press
  30.   Mauviel, A., Nallet-Staub, F., and Varelas, X. Integrating developmental signals: a Hippo in the (path) way. Oncogene. In press (Review)
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