Rodolphe FISCHMEISTER
  • E-mail :[email]
  • Phone : 0146835771
  • Location : Châtenay-Malabry, France
Last update 2015-05-14 14:03:08.213

Rodolphe FISCHMEISTER Ingénieur Supélec, Docteur-Ingénieur (PhD), Docteur ès Sciences

Course and current status

          PRESENT POSITION

Director of Research INSERM
Laboratoire de Signalisation et Physiopathologie Cardiovasculaire (INSERM UMR-S 1180)
University Paris-Sud, Faculty of Pharmacy
F-92296 Châtenay-Malabry Cedex, France
Tel: +33-1-46 83 57 71; Fax: +33-1-46 83 54 75
http://inserm-u1180.cep.u-psud.fr/index.php/en/
http://www.labex-lermit.fr/en/

 

EDUCATION

  • 1975: B.Sc. (Maths & Physics), University Paris-Sud, Orsay, France
  • 1978: Engineer Degree, Ecole Supérieure d'Eléctricité, Gif-sur-Yvette, France
  • 1980: Doctorat-Ingénieur (PhD), Physiology & Biophysics, University Paris-Sud, Orsay, France
  • 1987: Doctorat d'Etat ès Sciences Naturelles, University Paris-Sud, Orsay, France

 

APPOINTMENTS

  • 1981-1982: Post-doctoral Research Fellow, Department of Physiology & Biophysics, Dalhousie University, Halifax, Nova Scotia, Canada
  • 1982-1983: Research Associate in Anatomy, Dept of Anatomy, Emory University, Atlanta, Georgia, USA
  • 1983-1989: Research Associate INSERM, University Paris-Sud, Orsay, France
  • 1989-1992: Director of Research INSERM, University Paris-Sud, Orsay, France
  • 1992-1995: Director of Research INSERM, Head of Laboratory INSERM CJF 92-11, University Paris-Sud, Faculty of Pharmacy, Châtenay-Malabry, France
  • 1998-2001: Head of Institute IFR75 – Signalisation et Innovation Thérapeutique, University Paris-Sud, Faculty of Pharmacy, Châtenay-Malabry, France
  • 2003-2004: Visiting Professor, Department of Cell Biology, Emory University, Atlanta, Georgia, USA
  • 1996-2005: Director of Research INSERM, Head of Laboratory INSERM U446, University Paris-Sud, Faculty of Pharmacy, Châtenay-Malabry, France
  • 2006-: Director of Research INSERM, Head of Laboratory INSERM U769, University Paris-Sud, Faculty of Pharmacy, Châtenay-Malabry, France
  • 2006-2010: Head of Institute IFR141 - Innovation Thérapeutique: du Fondamental au Médicament, University Paris-Sud, Faculty of Pharmacy, Châtenay-Malabry, France
  • 2011-: Director of Research INSERM “Classe Exceptionnelle”
  • 2011-: Head of the Laboratory of Excellence in Research on Medication and Innovative Therapeutics (LabEx LERMIT)

 

HONOURS & AWARDS

  • 1978-1980: Délégation Générale à la Recherche Scientifique et Technique, Pre-doctoral Research Fellowship
  • 1981-1982: Nova Scotia Heart Foundation Post-doctoral Research Fellowship
  • 1982-1983: NIH Post-doctoral Research Fellowship
  • Head of INSERM Laboratory (1992-)
  • Founder and Head of the Institute of Signaling and Therapeutic Innovation (IFR75 ISIT) (1998-2001)
  • Founder and Head of the Institute of Therapeutic Innovation (IFR141 ITFM) (2006-)
  • Member (nominated) of INSERM Study Section CSS6 (1999-2002)
  • Member (elected) of the Research Council of the Faculty of Pharmacy of University Paris-Sud (1998-2001)
  • Member (elected) of the Research Council of the University Paris-Sud (2001-2004)
  • Editor for Journal of Physiology (1997-2005)
  • Editor for British Journal of Pharmacology (1999-2002)
  • Editor for Experimental and Clinical Cardiology (1997-)
  • Editor for European Journal of Heart Failure (2006-2009)
  • Associate Editor for Cardiovascular Research (2013-)
  • Reviewer for: American Journal of Physiology - Biochemical Pharmacology - Biophysical Journal - British Journal of Pharmacology – Cardiovascular Research – Cell Calcium – Circulation – Circulation Research – Cytoskeleton – European Journal of Neuroscience – FASEB Journal – FEBS Letters – Hypertension – Journal of the American College of Cardiology – Journal of Cell Science – Journal of Cellular Physiology – Journal of Cell Science – Journal of Clinical Investigation – Journal of General Physiology – Journal of Molecular and Cellular Cardiology – Journal of Pharmacology & Experimental Therapeutics – Journal of Physiology - Molecular Pharmacology – Nature Communications – Pediatric Research – Pflügers Archiv – Physiological Reviews – Proceedings of the National Academy of Sciences USA – Regulatory Peptides
  • Member (elected) of Academia Europaea (2007-)
  • Expert for the AERES (Agence d’Evaluation de la Recherche et de l’Enseignement Supérieur) (2007-)
  • Member of the Scientific Advisory Committee of the Institute of Molecular Medicine of Rangueil (I2MR), Toulouse, France (2008).
  • Member (nominated) of INSERM Study Section CSS4 (2008-2012)
  • President (elected) of INSERM Study Section CSS4 (2008-2012)
  • Member (nominated) of the Scientific Council of the Lefoulon-Delalande Fondation (2009-)
  • Member (nominated) of the Scientific Council for the ISHR-ES/Servier Fellowship (2010, 2012)
  • Member (nominated) of the Scientific Council for the Fondation pour la Recherche Médicale for Cardiovascular Research (2011)
  • Council member (elected) of the ISHR European Section (2010-)
  • Member of the External Advisory Committee of the “Centro de Investigação em Ciências da Saúde” (CICS-Universita di Beira Interior), Covilha, Portugal (2010-)
  • Brutsaert Lecturer of the Heart Failure Association of the European Society of Cardiology (2010)
  • Expert Panel member for the Government of Canada - Networks of Excellence of Canada (2012)
  • Founder and Head of the Laboratory of Excellence in Research on Medication and Innovative Therapeutics (LabEx LERMIT) (2011-)
  • Recipient of the Jeanne-Philippe Beziat Cardiology Prize of the Fondation pour la Recherche Médicale (2012)
  • Nominated FISHR - Fellow of the International Society for Heart Research (2013)
  • Expert Panel member for the Université Libre de Bruxelles (2013)
  • Recipient of the Alain Castaigne Prize of the Société Française de Cardiologie and AstraZeneca (2014)
  • Expert Panel member for the University Medical Center Utrecht (2014)
  • President-elect of the ISHR European Section (2014-2016)
  • Council member of the ISHR-International (2015-)

 

PROFESSIONAL ORGANIZATIONS (elected)

  • Academia Europaea
  • Biophysical Society
  • Physiological Society
  • Naturalia et Biologia
  • International Society for Heart Research (council member)
  • American Heart Association
  • Société de Biologie (council member)

 

PARTICIPATION TO MEETINGS (invited)

  • International Union of Physiological Sciences: Satellite Symposium on "Cardiac Muscle", Banff, Alberta, Canada, 21-22 July 1986
  • Workshop on "Computer Modeling of Membrane Currents and Ion Regulation in Cardiac Cells", Durham, NC, USA, 3-6 November 1986
  • 6° réunion annuelle de la Société Française de Biophysique: "Mouvements Ioniques dans les Membranes Biologiques", Orsay, France, 17-19 September 1987
  • Réunion annuelle du GRRC: "Biologie et Pathologie du Coeur et des Vaisseaux", Lyon-Bron, France, 28-29 April 1988 (co-organisateur d'une table ronde)
  • U.S.-Japan Seminar on "Mechanisms Regulating Initiation and Conduction of the Cardiac Impulse", Okazaki, Japan, 18-20 April 1988
  • International Symposium on "Basic Mechanisms of Arrhythmias", Tokyo, Japan, 22-23 April 1988 (co-chairman d'une session)
  • Bayer Centenary Symposium: "The Calcium Channel: Structure, Function and Implications", Stresa, Italy, 11-14 May 1988
  • XIII Congress of the International Society of Heart Research: Satellite Symposium on "Subcellular Basis of Cardiac Failure", Ottawa, Canada, 12-13 May 1989
  • Journées "Patch-Clamp", Paris, France, 24-25 May 1989
  • Symposium "Couplage Excitation-Sécrétion", Orford, Québec, Canada, 15-17 June 1989
  • Premier Colloque "Canaux Ioniques", Carry-le-Rouet, France, 18-20 October 1990
  • NATO Advanced Research Workshop on "Intracellular Modulators of Cardiac and Neuronal Ion Channels", Il Ciocco, Italy, 24-27 Avril 1991
  • Conférence Jacques Monod sur "Molecular Biology of G proteins and Associated Molecules", Aussois, France, 2-8 Juin 1991
  • Regional Meeting of Physiological Sciences, International Union of Physiological Sciences, Prague, Czechoslovakia, 30 June - 5 July 1991
  • 3ème Colloque "Canaux Ioniques", Carry-le-Rouet, France, 15-17 October 1992 (main organizer)
  • XVème Séminaire de Cardiologie Fondamentale, 25-26 March 1993, Clermont Ferrand, France
  • International Society for Heart Research, XIV European Section Meeting, 9-13 May 1993, Jérusalem, Israel
  • Cinquièmes Rencontres de Cardiologie, 27-28 May 1993, Pouligny-Notre-Dame, France
  • The Fourth Antwerp-La Jolla-Kyoto Research Conferences on Cardiac Function "Endothelial Control of Cardiac Performance", 28-29 June 1993, Anvers, Belgium
  • Conférence Jacques Monod sur "Molecular and Cellular Biology of Guanine Nucleotide-Binding Regulatory Proteins", 6-12 June 1993, Aussois, France
  • XXXII International Union of Physiological Sciences Meeting, 1-6 August 1993, Glasgow, Royaume-Uni
  • International Symposium "Structure and Function in Biological Systems", 20-23 September 1993, Würzburg, R.F.A. (chairman)
  • ASPET Biology '94 Meeting, Symposium "Multiple Phosphodiesterases: Cellular Regulation", 23 April 1994, Anaheim, Californie, U.S.A.
  • Colloque "Design in neural perception and integration", Marseille, France, 19-20 May 1994
  • Symposium "New Trends in Pharmacology and Pathophysiology of Heart Muscle Contraction", 9-11 June 1994, Hamburg, Germany
  • Symposium "Molecular Mechanisms Underlying Regulation of Cardiac Cell Function", 8-10 July 1994, Tokyo, Japan
  • 17th Annual Meeting of the European Neuroscience Association, Vienna, Austria, 4-8 September 1994
  • Conférences Ste Odile, 16-19 September 1994, Mont-Ste-Odile, France
  • 3ème Forum pluridisciplinaire organisé par le Club NO."Le Point sur NO: résultats, controverses, perspectives", 16 March 1995, Paris, France
  • "The Second International Meeting on Endothelial Control of Cardiac Performance", Anvers, Belgium, 28-30 June 1995
  • "Cologne Conference on Heart Failure 1995: Signal Transduction in cardiac hypertrophy and Failure", Cologne, Germany, 25-27 May 1995
  • The XVth World Congress of the ISHR, Prague, Czech Republic, 2-7 July 1995 (chairman de session)
  • 13ème Congrès de la Société d'Endocrinologie, Nancy, France, 31 August-1er September 1995
  • William Harvey Research Conferences on Phosphodiesterase Inhibitors and their Therapeutical Potential, London, UK, 21-22 June 1995
  • Séminaires du Collège de France: Signalisation Intracellulaire, Paris, 12-13 January 1996
  • VIIIème Réunion du GERS, Paris, France, 22 March 1996
  • GRRC, Lyon, France, 2-3 April 1996
  • Réunions Scientifiques de l'Institut Paris-Sud sur les Cytokines, Châtenay-Malabry, France, 4 April 1996
  • XVIII Meeting ISHR, North American Section, Chicago, U.S.A., 9-13 June 1996
  • 64ème Congrès de l'Association Canadienne-Française pour l'Avancement des Sciences, Colloque Arythmies Cardiaques: de la cellule au patient, Montreal, Canada, 13-17 May 1996
  • 3rd International Conference on Cyclic Nucleotide Phosphodiesterases, 18-21 July 1996, Glasgow, UK
  • The Seventh International Symposium on Subtypes of Muscarinic Receptors, Vienna, Virginia, U.S.A., 12-15 November 1996
  • XVII European Congress ISHR, Bologna, Italy, 18-21 June 1996
  • 2nd Czech-French-Slovak Symposium New Frontiers in Basic Cardiovascular Research, Smolenice, Slovakia, 16-19 May 1996
  • Congrès d’Endocrinologie Comparée, Oujda, Maroc, 18-20 December 1997
  • 22ème Symposium Européen (organisé avec l’aide de l’INSERM) Hormones and Cell Regulation, Mont Sainte-Odile, France, 3-6 October 1997
  • Réunion du Club NO, Paris, France, 9 June 1998
  • 3rd Czech-French-Slovak Symposium New Frontiers in Basic Cardiovascular Research, Obernai, France, 7-10 May 1998
  • XVI World Congress of the ISHR, Rhodes, Greece, 27-31 May 1998
  • Joint Meeting of the Czech and British Physiological Societies, Prague, Czech Republic, 22-24 June 1998
  • 4th International Dead Sea Symposium on Advances in Diagnosis and Treatment of Cardiac Arrhythmias, Hyatt Regency Dead Sea Resort & Spa, Israel, 3-6 March 1998
  • Gordon Research Conference on Cardiac Regulatory Mechanisms, Colby-Sawyer College, New London, NH, USA, 19-24 July 1998
  • 1st Oslo Conference on Molecular Cardiology and Myocardial Function, Oslo, Norway, 24-26 May 1999
  • 2nd FEPS Congress, Prague, Czech Republic, 29 June – 4 July 1999
  • 1949-1999: 50 Years of Cardiac Cellular Electrophysiology - A Tribute to Professor Édouard Coraboeuf. Orsay, France, 8-10 September 1999 (main organizer)
  • 11ème Séminaire « Club de la Transplantation », Abbaye des Vaux de Cernay, France, 14-15 October 1999
  • XIIème Colloque Biotechnocentre, Domaine de Seillac, France, 4-5 November 1999
  • NATO Workshop on Ca2+ Signaling and Cross Talk, Lucca, Italy, 25-30 April 2000
  • International Symposium of the Slovak Academy of Sciences, Smolenice, Slovaky, 4-7 June 2000
  • International Society for Autonomic Neuroscience, 2nd International Congress, London, UK, 17-21 July 2000
  • 12th Protein Kinase (NO/cGMP) Symposium, Bad Brückenau, Germany, 31 August-3 September 2000
  • 4th Czech-French-Slovak Symposium New Frontiers in Basic Cardiovascular Research, Marienbad, Czech Republic, 5-8 October 2000
  • Heart Failure 2001, Barcelona, Spain, 9-12 June 2001
  • Gordon Research Conference on Calcium Signaling, Oxford, UK, 2-7 September 2001
  • 12th International Symposium on “Calcium Binding Proteins and Calcium Function in Health and Disease”, Cavalese, Italy, 29 January – 3 February 2002
  • Colloquium on “Frontiers in Molecular Pharmacology and Physiology”, Munich, Germany, 31 May – 1st June 2002
  • Gordon Research Conference on “Cyclic Nucleotide Phosphodiesterases”, Mt. Holyoke, USA, 23-28 June 2002
  • 5th Czech-French-Slovak Symposium New Frontiers in Basic Cardiovascular Research, Smolenice, Slovakia, 4-7 October 2002
  • Joint Meeting of the Deutsche Forschungsgemeinschaft with the Sonderforschungsbereich on "Pathophysiology of Heart Failure", Münster, Germany, 6-8 December 2002 (opening Lecture)
  • Heart Failure 2003 and Annual Congress of the European Section of the ISHR, Strasbourg, 21-24 June 2003
  • Gordon Research Conference - Cyclic Nucleotide Phosphodiesterases. Il Ciocco, Italy, 30 May – 4 June 2004 (invited but passed on colleague)
  • Nitric Oxide: Comparative Aspects of Respiratory and Cardiovascular Homeostasis, Society for Experimental Biology, Capri, Italy, 10-13 September 2004
  • 15th Colloque Canaux Ioniques, Presqu’île de Giens, 19-22 September 2004 (plenary lecture)
  • Compartmentalized Signalling by Kinases and Phosphatases, 14th Protein Kinase Symposium, Oslo, Norway, 23-26 September, 2004
  • Symposium on Pioneers of Physiological Research and Challenges for 21st Century Physiologists, Seoul, Korea, 28-29 October 2004
  • Annual Meeting of the GRRC:"Biologie et Pathologie du Coeur et des Vaisseaux", Strasbourg, France, 21-22 April 2005 (plenary lecture)
  • 25th European Section Meeting of the ISHR, Tromsø, Norway, 21-25 June 2005
  • 4th International Mammalian Myocardium Meeting, Leeds, UK, 17-20 July 2005
  • 2nd Annual AHA Basic Science Council Conference on Heart Disease, Keystone, USA, 24-27 July 2005.
  • XXVes Journées de l’HTA, Paris, 15-16 December 2005
  • Biochemical Society Meeting Compartmentalization of cyclic AMP signalling, Cambridge, UK, 29-30 March 2006 (invited but passed on colleague)
  • 5th International Ascona Workshop - Cardiomyocyte Cell Biology: Differentiation, Stability of Cytoarchitecture and Therapeutic Potential of Heart Muscle Cells. Ascona, Switzerland, 2-6 April 2006 (co-organizer)
  • Gordon Research Conference - Cyclic Nucleotide Phosphodiesterases. University of New England, Biddeford, ME June 4-9, 2006
  • 15th Protein Kinase Meeting - Spatial and Temporal Regulation of Signalling. FEBS/EMBO Workshop. Oslo, Norway, 21-24 September 2006
  • Leducq mini-symposium - Localized Control of cAMP Signaling in Cardiac Cells. Paris, France, 19 September 2006 (organizer)
  • New Frontiers in Basic Cardiovascular Research - Subcellular mechanisms of altered muscle function in cardiovascular diseases, Debrecen, Hongrie, 5-8 octobre 2006.
  • Scientific Advisory Committee Meeting of the Leducq Foundation, Berlin, Germany, 26-27 October 2007
  • XVIIes Journées Européennes de la Société Française de Cardiologie. Paris, France, 17-20 January 2007
  • 2nd Annual European Heart Failure Winter Research Meeting. Garmisch-Partenkirchen, Germany, 24-27 January 2007
  • Azur-Heart Meeting on Molecular and Cellular Biology of Heart Failure, Carry-le-Rouet, France, 1-3 June 2007 (co-organizer)
  • 13ème Journée Scientifique de l’IFRMP23, Le Havre, France, 8 juin 2007 (conférence de clôture)
  • 3rd International Conference on cGMP Generators, Effectors and Therapeutic Implications, Dresden, Germany, 15-17 June 2007
  • 27th European Section Meeting of the ISHR. Padova and Abano, Italy, 20-22 June 2007
  • XIXth World Congress of the ISHR - From Cell to Man to Society. Bologna, Italy, 22-26 June 2007
  • France-China Forum on Cardiovascular Molecular Medicine, Beijing, China, 4-7 July 2007 (co-organizer)
  • 2nd International Conference on Anchored cAMP Signaling Mechanisms, Portland, Oregon, USA, 12-14 October 2007
  • Scientific Advisory Committee Meeting of the Leducq Foundation, Rome, Italy, 25-26 October 2007
  • American Heart Association Meeting, Circulation Research Symposium on PDE, Orlando, USA, 4-7 November 2007
  • Nato-Nrarw Translational Knowledge For Heart Health, Istanbul, Turkey, 12-16 May 2008
  • Annual Meeting of the GRRC:"Biologie et Pathologie du Coeur et des Vaisseaux", Printemps de la Cardiologie, Montpellier, France, 28-31 Mai 2008.
  • Joint 8th Meeting of France-New EU Members and the 16th JMRC Symposium “New Frontiers in Cardiovascular Research”, Kraków, Poland, 5-7 June 2008 (invited but passed on colleague).
  • Gordon Research Conference on Cyclic Nucleotide Phosphodiesterases, Il Ciocco, Italy, June 8-13, 2008
  • Workshop on Methods in Pharmacological Research, Manchester, UK, July 17-19, 2008 (invited but passed on colleague).
  • Mendel Symposium II: Genes and the Heart, Liblice Castle, Prague, Czech Republic, September 24-27, 2008
  • Satellite Meeting of JIC, Surat 2008, Translational Research in Cardiovascular Sciences: from bench to bedside and vice versa, The Maharaja Sayajirao University of Baroda, Fatehguni, Vadodara, India, December 11, 2008. (invited but could not attend)
  • Leducq Transatlantic Network Symposium, Promising Avenues of Research in Heart Failure, Paris, France, April 2, 2009
  • 26th Annual Meeting of the GRRC: "Biologie et Pathologie du Coeur et des Vaisseaux", Nancy, France, April 2-3, 2009.
  • Rencontres de Cardiologie, 17-19 June 2009, Chantilly, France
  • 1st CODDIM Colloquium, 29 September 2009, Paris, France (session Chairman)
  • Heart Failure Association of the European Society of Cardiology, Translational Winter Research Meeting on Heart Failure, 27-30 January 2010, Les Diablerets, Switzerland (Brutsaert Keynote Lecture)
  • Symposium on Scientific Basis for the Practice of Cardiology, 8-11 April 2010, Prague, Czech Republic
  • Printemps de la Cardiologie, Nantes, France, April 15-17, 2010.
  • Heart Failure 2010, 29 May – 1st June 2010, Berlin, Germany
  • The 5th International Symposium on the Mammalian Myocardium, 27-29 June 2010, Manchester, United Kingdom
  • 2ème Journée Scientifique de la FR3209 Bioingénierie Moléculaire, Cellulaire et Thérapeutique, Nancy, France, 2nd July 2010.
  • Frontiers in Computational Electrocardiology III, Focus on Systems Biology, 11 November 2010, Maastricht, The Netherlands.
  • EUGeneHeart Symposium, 3rd December 2010, Brussels, Belgium.
  • Heart Failure Association of the European Society of Cardiology, Translational Winter Research Meeting on Heart Failure, Les Diablerets, Switzerland, 26-29 January 2011.
  • Printemps de la Cardiologie, Lyon, France, May 12-14, 2011.
  • ISHR European Section Annual meeting 2011, Haifa, Israel, 26-29 June 2011.
  • European Society of Cardiology 2011 Congress, Paris-Nord Villepinte, 27-31 August 2011.
  • International Conference on Heart Failure with Preserved Ejection Fraction: Basic mechanisms, Budapest, Hungary, 23-25 September 2011.
  • Société de Biologie – Séance sur les Nouvelles avancées en cardiologie expérimentale et clinique, Paris, 19 Octobre 2011 (invited organiser and speaker).
  • Heart Failure Association of the European Society of Cardiology, Translational Winter Research Meeting on Heart Failure, Les Diablerets, Switzerland, 18-21 January 2012.
  • Printemps de la Cardiologie, Bordeaux, France, April 12-13, 2012.
  • Gordon Research Conference on Cyclic Nucleotide Phosphodiesterases, Il Ciocco, Italy, May 20-25, 2012.
  • Heart Failure Congress 2012, Belgrade, Serbia, 19-22 May 2012.
  • New Frontiers in Basic Cardiovascular Research 2012, 10th Meeting of France – New EU Member Countries, Hradec Králové, Czech Republic, 12-15 June 2012 (organizer and keynote lecture).
  • European Society of Cardiology Working Group on Cardiac Cellular Electrophysiology, Nantes, France, 15-16 September 2012 (keynote lecture).
  • Heart Failure Association of the European Society of Cardiology, Translational Winter Research Meeting on Heart Failure, Les Diablerets, Switzerland, 23-26 January 2013.
  • Novel Functions for Cyclic Nucleotide Phosphodiesterases and their Implications for Pharmacological Intervention, ASPET Annual Meeting at Experimental Biology, April 20-24, 2013, Boston, USA.
  • Heart Failure Congress 2013, 25-28 May 2013, Lisbon, Portugal
  • 3rd International Workshop on cAMP on protein kinase and phosphodiesterases: from genetics to function and human diseases, 11-12 May 2013, Paris, France.
  • DZHK/SFB1002 Workshop on “Cardiac second messenger microdomains”, 12 September 2013, Göttingen, Germany.
  • ITMO CMN - Séminaire Franco-Allemand en Recherche Cardiovasculaire, 22 novembre 2013, Paris, France.
  • Heart Failure Association of the European Society of Cardiology, Translational Winter Research Meeting on Heart Failure, Les Diablerets, Switzerland, 22-25 January 2014.
  • HFA Translational Research Workshop, Treatments targeting inotropy: New hope for an old concept or “The Emperor´s new clothes”?, Brussels, Belgium, March 10-11, 2014.
  • Printemps de la Cardiologie, Strasbourg, France, April 24-25, 2014.
  • Rencontres de Cardiologie 2014 « Coeur & Mitochondrie », 21-23 May 2014, Chantilly, France
  • Gordon Research Conference on Cyclic Nucleotide Phosphodiesterases, 1-6 June 12014, Mount Holyoke College, South Hadley, MA, USA (vice-chair of the conference).
  • 11th New Frontiers in Basic Cardiovascular Research conference, Smolenice Castle, Slovakia, June 15-19, 2014 (co-organizer).
  • 3rd Frontiers in CardioVascular Biology (FCVB) meeting, Barcelona, Spain, 4-6 July 2014.
  • ESC Congress 2014, Barcelona, Spain, 30 August - 03 September 2014 (could not attend).
  • American Heart Association Scientific Sessions 2014, Chicago, Illinois, USA, 15-19 November 2014.
  • 25es Journées Européennes de la Société Française de Cardiologie. Paris, France, 14-17 January 2015
  • Heart Failure Association of the European Society of Cardiology, Translational Winter Research Meeting on Heart Failure, Les Diablerets, Switzerland, 21-24 January 2015.
  • 81st Annual Congress of the German Society for Experimental and Clinical Pharmacology and Toxicology (DGPT), Kiel, Germany, 10-12 March 2015.
  • 33rd European Section meeting of the International Society for Heart Research, Bordeaux, France, 1-4 July 2015 (co-organizer).
  • FEPS 2015, Joint Meeting of the Federation of European Physiological Societies and the Baltic Physiological Societies in Kaunas, Lithuania, 26-29 August 2015.

 

SEMINARS (invited)

  • UCLA, The Jerry Lewis Neuromuscular Research Center, Los Angeles, CA, USA, 1983
  • UCLA, Dept. of Physiology, Los Angeles, CA, USA, 1983
  • Univ. of California San Francisco, Dept. of Pharmacology, San Francisco, CA, USA, 1983
  • Univ. of Pennsylvania, Dept. of Physiology, Philadelphia, PA, USA, 1983
  • Univ. of Texas Medical Branch, Dept. of Physiology & Biophysics, Galveston, TX, USA, 1983
  • Emory Univ., Dept. of Pharmacology, Atlanta, GA, USA, 1984
  • Universita di Torino, Dipartimento di Biologia Animale, Torino, Italy, 1984
  • Universität des Saarlandes, II. Physiologisches Institut, Homburg/Saar, Germany, 1985
  • Universidad Central de Venezuela, Escuela de Biologia, Caracas, Venezuela, 1985
  • Instituto Venezolano de Investigaciones Cientificas, Dipto. de Fisiologia, Caracas, Venezuela, 1985
  • Medical College of Georgia, Dept. of Anatomy, Augusta, GA, USA, 1986
  • SUNY, Dept. of Physiology and Biophysics, Stony Brook, NY, USA, 1986
  • SUNY, Dept. of Biophysical Sciences, Buffalo, NY, USA, 1986
  • INSERM U-127, Hôpital Lariboisière, Paris, France, 1986
  • Yale Univ., Dept. of Physiology, New Haven, CT, USA, 1986
  • Univ. of Rochester, School of Medicine and Dentistry, Rochester, NY, USA, 1986
  • Ruhr Universität Bochum, Dept. of Cell Physiology, Bochum, Germany, 1986
  • Juntendo Univ., Dept. of Physiology, Tokyo, Japan, 1988
  • Kyushu Univ., Dept. of Pharmacology, Fukuoka, Japan, 1988
  • Yamagata Univ., Dept. of Pharmacology, Yamagata, Japan, 1988
  • Niigata Univ., Dept. of Pharmacology, Niigata, Japan, 1988
  • Hiroshima Univ., Dept. of Physiology, Hiroshima, Japan, 1988
  • CNRS, Lab. Régulations Physiologiques, Strasbourg, France, 1988
  • State Univ. of New York, Dept. of Medicine, Brooklyn, NY, USA, 1989
  • Marshall Univ., Dept. of Pharmacology, Huntington, WV, USA, 1989
  • INSERM U-99, Hôpital Henri-Mondor, Créteil, France, 1989
  • Max-Planck-Institut für Psychiatrie, Munich, Germany, 1989
  • Medizinische Universität Klinik, Würzburg, Germany, 1990
  • Emory Univ., Dept. of Anatomy & Cell Biology, Atlanta, USA, 1990
  • Bayer A.G., Dept. of Pharmacology, Wuppertal, Germany, 1991
  • Univ. Illinois at Chicago, Dept. of Pharmacology, Chicago, IL, USA, 1991
  • Centre de Recherche en Biochimie Macromoléculaire, CNRS-INSERM, Montpellier, France, 1991
  • INSERM U-195, Faculté de Médecine, Clermont-Ferrand, France, 1992
  • Service de Cardiologie, Hôpital Pitié-Salpétrière, Paris, France, 1992
  • INSERM U-8, Bordeaux, France, 1992
  • Centre de Recherche GLAXO, Les Ulis, France, 1993
  • INSERM, Hôpital Saint Antoine, Paris, France, 1993
  • Laboratoires Hoechst, Puteaux, France, 1993
  • Institut Curie, Paris, France, 1994
  • CNRS URA 1159, Le Plessis-Robinson, France, 1994
  • INSERM U-275, Palaiseau, France, 1994
  • University of Seoul, Seoul, South Korea, 1994
  • INSERM U-337, Paris, France, 1995
  • Freie Universität Berlin, Institut für Pharmakologie, Berlin, Germany, 1996
  • Max Delbruck Center für Molekular Medizin, Berlin, Germany, 1996
  • Emory University, Atlanta, U.S.A., 1997
  • Laboratoires Janssen, Beerse, Belgium, 1997
  • Laboratoires SmithKline & Beecham, Rennes, France, 1997
  • Laboratoires Servier, Puteaux, France, 1997
  • Laboratoires Pierre Fabre, Castres, France, 1997
  • Universitaat Leuven, Belgium, 1997
  • Université de Rouen, France, 1998
  • Universita di Calabria, Cosenza, Italy, 1998
  • Medical Academy, Institute of Cardiology, Kaunas, Lithuania, 1998
  • Laboratory of Cardiovascular Science, NIA-NIH, Baltimore, 1999
  • INSERM U-99, Créteil, France, 1999
  • Université Libanaise, Beyrouth, Lebanon, 2000
  • Université Louis Pasteur, Strasbourg, France, 2000
  • Université de Montpellier, France, 2001
  • Université Mohammed 1er, Oujda, Morocco, 2002
  • University of Bern, Switzerland, 2003
  • Veterans Administration Hospital, Atlanta, 2003
  • Emory University, Atlanta, 2004
  • University of Cincinnati, Cincinnati, 2004
  • Duke University, Durham, 2004
  • University of Vermont, Burlington, 2004
  • Northwestern University, Chicago, 2004
  • McGill University, Montreal, 2004
  • Cambridge University, Cambridge, 2004
  • Hôpital Necker, Paris, 2005
  • Université de Poitiers, Poitiers, 2005
  • Universidade da Beira Interior, Covilha, Portugal, 2005
  • CHU Rangueil, Toulouse, 2005
  • CHU Nantes, 2006
  • CHU Pitié-Salpétrière, Paris, 2006
  • University Medical Center Hamburg-Eppendorf, Hamburg, Germany, 2006
  • Scios Inc., Fremont, California, USA, 2006
  • Institute of Biophysics, Chinese Academy of Sciences, Beijing, China, 2006
  • Peking University, Beijing, PR China, 2006
  • Shanghai Institute of Biological Sciences, Chinese Academy of Sciences, Shanghai, PR China, 2006
  • Stanford University School of Medicine, Department of Molecular and Cellular Physiology, Stanford, USA, 2007
  • University of Innsbruck, Department of Pharmacology and Toxicology, Innsbruck, Austria, 2007
  • Academy of Sciences of the Czech Republic, Institute of Physiology, Prague, Czech Republic, 2007
  • King's College London, London, UK, 2008
  • Columbia University, New York, USA, 2009
  • University of Medicine and Dentistry of New Jersey, Newark, USA, 2009
  • State University of New York Downstate, New York, USA, 2009
  • University of Washington, Seattle, USA, 2009
  • Université Mohammed 1er, Oujda, Morocco, 2009
  • University of Oslo, Dept Pharmacology, Oslo, Norway, 2010
  • Cardiovascular Research Institute, Maastricht University Medical Centre, Maastricht, The Netherlands, 2010
  • Georg August University Medical Center, Göttingen, Germany, 2010
  • Institut de Génomique Fonctionnelle, University of Montpellier, Montpellier, France, 2010
  • University of Illinois at Chicago College of Medicine, USA, 2011
  • Loyola University Medical Center, Maywood, USA, 2011
  • Groupe de Recherche Servier, Suresnes, France, 2012
  • University of Oslo, Center for Heart Failure Research, Oslo, Norway, 2012
  • Université Mohammed 1er, Oujda, Morocco, 2012
  • Institute of Biophysics, Chinese Academy of Sciences, Beijing, China, 2012
  • Cardiovascular Grand Rounds – CARIM Maastricht University, Maastricht, The Netherlands, 2013
  • Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK, 2014
  • Jagiellonian Centre for Experimental Therapeutics (JCET), Jagiellonian University, Krakow, Poland, 2014
  • Graduiertenkolleg 1873, Life and Brain Institute, Universität Bonn, Bonn, Germany, 2014

 

PUBLICATIONS (>160 in total, >7500 citations, 20 papers cited >100 times, H-index=50)

10 Major Publications:

  • Hartzell, H. C. & Fischmeister, R. (1986). Opposite effects of cyclic GMP and cyclic AMP on Ca2+ current in single heart cells. Nature 323, 273-275. PMID: 2429189
  • Méry, P. F., Brechler, V., Pavoine, C., Pecker, F. & Fischmeister, R. (1990). Glucagon stimulates the cardiac Ca2+ current by activation of adenylyl cyclase and inhibition of phosphodiesterase. Nature 345, 158-161. PMID: 2159595
  • Méry, P. F., Lohmann, S. M., Walter, U. & Fischmeister, R. (1991). Ca2+ current is regulated by cyclic GMP-dependent protein kinase in mammalian cardiac myocytes. Proc. Natl. Acad. Sci. USA 88, 1197-1201. PMID: 1705030
  • Hartzell, H. C., Méry, P. F., Fischmeister, R. & Szabo, G. (1991). Sympathetic regulation of cardiac calcium current is due exclusively to cAMP-dependent phosphorylation. Nature 351, 573-576. PMID: 1710784
  • Jurevičius, J. & Fischmeister, R. (1996). Cyclic AMP compartmentation is responsible for a local activation of cardiac Ca2+ channels by b-adrenergic agonists. Proc. Natl. Acad. Sci. USA 93, 295-299. PMID: 8552625
  • Vandecasteele, G., Eschenhagen, T., Scholz, H., Stein, B., Verde, I. & Fischmeister, R. (1999). Muscarinic and b-adrenergic regulation of heart rate, force of contraction and Ca2+ current is preserved in mice lacking endothelial nitric oxide synthase. Nature Medicine 5, 331-334. PMID: 10086391
  • Castro, L. R. V., Verde, I., Cooper, D. M. F. & Fischmeister, R. (2006). Cyclic guanosine monophosphate compartmentation in rat cardiac myocytes. Circulation 113, 2221-2228. PMID: 16651469
  • Skeberdis, V. A., Gendviliene, V., Zablockaite, D., Treinys, R., Macianskiene, R., Bogdelis, A., Jurevičius, J. & Fischmeister, R. (2008). ß3-adrenergic receptor activation increases human atrial tissue contractility and stimulates the L-type Ca2+ current. J Clin Invest 118, 3219-3227. PMID: 18704193
  • Molina, C. E., Leroy, J., Xie, M., Richter, W., Lee, I.-O., Maack, C., Rucker-Martin, C., Donzeau-Gouge, P., Verde, I., Hove-Madsen, L., Barriga, M., Conti, M., Vandecasteele, G. & Fischmeister, R. (2012). Cyclic AMP phosphodiesterase type 4 protects against atrial arrhythmias. J Am Coll Cardiol 59, 2182-2190. PMID: 22676938
  • Mehel#, H., Emons#, J., Vettel, C., Wittköpper, K., Seppelt, D., Dewenter, M., Lutz, S., Sossalla, S., Maier, L. S., Lechêne, P., Leroy, J., Lefebvre, F., Varin, A., Eschenhagen, T., Nattel, S., Dobrev, D., Zimmermann, W.-H., Nikolaev, V. O., Vandecasteele, G., Fischmeister, R.* & El-Armouche, A. * (2013). Phoshodiesterase-2 is upregulated in human failing hearts and blunts ß-adrenergic responses in cardiomyocytes. J Am Coll Cardiol 62, 1596-1606 (#,*equal contributions). PMID: 23810893

 

Major reviews

  • Lohmann, S. M., Fischmeister, R. & Walter, U. (1991). Signal transduction by cGMP in heart. Basic Res. Cardiol. 86, 503-514.
  • Hartzell, H. C. & Fischmeister, R. (1992). Direct regulation of cardiac Ca channels by G proteins: neither proven nor needed ? Trends Pharmacol. Sci. 13, 380-385.
  • Hove-Madsen, L., Méry, P.-F., Jurevičius, J., Skeberdis, A. V. & Fischmeister, R. (1996). Regulation of myocardial calcium channels by cyclic AMP metabolism. Basic Res. Cardiol. 91(Suppl. 2), 1-8.
  • Méry, P. F., Abi-Gerges, N., Vandecasteele, G., Jurevičius, J., Eschenhagen, T. & Fischmeister, R. (1997). Muscarinic regulation of the L-type calcium current in isolated cardiac myocytes. Life Sci. 60, 1113-1120.
  • Langlois, M. & Fischmeister, R. (2003). 5-HT4 receptor ligands: applications and new prospects. J. Med. Chem. 46, 319-344.
  • Fischmeister, R., Castro, L., Abi-Gerges, A., Rochais, F. Vandecasteele, G. (2005) Species- and tissue-dependent effects of NO and cyclic GMP on cardiac ion channels. Comp. Biochem. Physiol. 142, 136-143.
  • Fischmeister, R. (2006) Is cAMP good or bad? Depends on where it’s made. Circ. Res. 98, 582-584.
  • Vandecasteele, G., Rochais, F., Abi-Gerges, A. & Fischmeister, R. (2006). Functional localization of cAMP signalling in cardiac myocytes. Biochem Soc Trans 34, 484-4888.
  • Fischmeister, R., Castro, L. R. V., Abi-Gerges, A., Rochais, F., Jurevičius, J., Leroy, J. & Vandecasteele, G. (2006). Compartmentation of cyclic nucleotide signaling in the heart: The role of cyclic nucleotide phosphodiesterases. Circ Res 99, 816-828.
  • Rochais, F. & Fischmeister, R. (2010). Acute cardiac effects of Neuregulin-1/ErbB signaling. Cardiovasc Res 88, 393-4.
  • Mika, D., Leroy, J., Vandecasteele, G. & Fischmeister, R. (2012). PDEs create local domains of cAMP signaling. J Mol Cell Cardiol 52, 323-329.
  • Guellich, A., Mehel, H. & Fischmeister, R. (2014). Cyclic AMP synthesis and degradation in the normal and failing heart. Pflügers Arch 466, 1163-1175.

 

PATENTS

  • INSERM Patent (FR 97 15 037; WO 99/28456): Splice variants for human 5-HT4 serotonin receptors and their applications, in particular for screening.
  • CEREP/CNRS Patent (FR 01 02 431 ; WO 02/068399) : Aryl carbamate derivatives, preparation and use thereof.
  • INSERM Patent (PCT/EP2013/069298, WO2014053315): Tetrahydroquinoline derivatives and their use as Epac inhibitors.

Scientific summary

AREA OF RESEARCH

Cardiac physiology - cardiovascular pharmacology - neuroendocrine regulation of heart function - cardiac electrophysiology - cyclic nucleotide signaling - intracellular compartmentation - molecular mechanisms of ion movement through ionic channels - cellular control of ion channels and active transport systems - pharmacology of cardiac ion channels.

The cyclic nucleotides (CN) cAMP and cGMP participate in the main regulations of cardiac function. They act as second messengers for sympathetic and parasympathetic systems, nitric oxide (NO) and natriuretic peptides. CN may exert beneficial or deleterious effects on the heart, depending on the duration of the stimulation. Acute elevation of CN regulate cardiac excitation-contraction coupling. However, chronic elevation of cAMP contributes to the development of cardiac hypertrophy and progression to heart failure (HF), while cGMP possesses anti-hypertrophic properties. Our work over the last years has been dedicated to understanding the intracellular organization of CN pathways, which we found are highly compartmentalized, and the changes occurring in pathophysiological situations. The general objective is to understand the molecular mechanisms responsible for the homeostasis of these two second messengers and the functional consequences for cellular and cardiac function. We developed novel electrophysiological and imaging techniques to record simultaneously cyclic nucleotide changes and key functional parameters of the cardiac cell.

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