• E-mail :[email]
  • Phone : +33 4 37 91 12 49
  • Location : LYON, France
Last update 2019-02-15 15:25:16.413


Course and current status

University studies

2011: HDR "Habilitation à Diriger des Recherches". (Degree necessary to supervise PhD students in France). University Claude Bernard Lyon I.

1998: PhD in Neuroscience, University Pierre et Marie Curie, Paris VI.

Professional experience

1995-1998: PhD under the supervision of Prof Jean-Michel Deniau in the laboratory of Prof Marie-Jo Besson. University Pierre et Marie Curie. Paris, FRANCE.

1999-2001: Post-PhD at NIH, Bethesda, Maryland, USA. Dir: Prof. Steven E. Hyman.
2002: 2nd Post-Ph.D at Rockefeller University, New York City. Dir: Prof. Paul Greengard.
2003-2004: Full time researcher (CR2) at INSERM. Inserm U318, Grenoble, France. Dir: Prof. Alim-Louis Benabid.
2005-2008: Full time researcher (CR1) at INSERM. Inserm U704 (Dir: Dr Marc Savasta) and then U836 (Dir: Prof. Claude Feuerstein), Grenoble, France.
2009-present : Full time researcher (CR1) at INSERM. Laboratory of CNRS UMR 5229 (Dir: Dr Jean-Rene Duhamel; Since January 1, 2017: Dr Angela SIRIGU). Bron, France.

Research interests

Physiopathology of basal ganglia; Clinical, physiopathological and pharmacological  aspects of Parkinson's disease; Movement disorders; Behavioral disorders. 

Scientific summary

My research formation started in 1993 when I was in Montreal. I was studying in the lab of Dr Réjean Couture, the effects of tachykinin agonists and antagonists on a nociceptive spinal reflex in the rat. My research formation continued when I performed my master degree in Paris under the supervision of Prof Jean-Michel Deniau. During this period I studied the effects of electrical stimulation of the cerebral cortex on the expression of c-fos, an immediate early gene, in the basal ganglia on anaesthetized rat. During my PhD (September 1995 - December 1998), I did pursue the study of this experimental model to analyze molecular mechanisms (c-fos, zif268) of synaptic plasticity and signal transduction (MAP Kinases ERK, Elk-1 and CREB transcription factors) driven by electrical stimulation of the orofacial motor cortex with Dr Jocelyne Caboche. I then went to the NIH as a visiting fellow in the lab of Dr Steven E Hyman (was director of NIMH then Provost at Harvard) to characterize the expression and function of two new genes, ania-6 and ania-3, by molecular, cellular and biochemical approaches (1999-2002). I did perform a second post-doctoral training (2002) in the laboratory of Prof Paul Greengard (Nobel prize of medicine in 2000) at Rockefeller university in New York where I studied the role of DARPP-32 in the regulation of gene expression in response to cocaine in mice. I got an academic position at INSERM in 2002 and joined the laboratory of Prof Alim-Louis Benabid in January 2003 to investigate the phenotypic plasticity of basal ganglia neurons in response to either deep brain stimulation of the subthalamic nucleus or levodopa treatment, the two major symptomatic treatments for Parkinson’s disease, by using rodent models and combining behavioral and immunohistochemical approaches. In 2009, I moved to Lyon (CNRS UMR 5229) to work on motor and non-motor symptoms of PD in primates. 

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