2011: HDR "Habilitation à Diriger des Recherches". (Degree necessary to supervise PhD students in France). University Claude Bernard Lyon I.
1998: PhD in Neuroscience, University Pierre et Marie Curie, Paris VI.
1995-1998: PhD under the supervision of Prof Jean-Michel Deniau in the laboratory of Prof Marie-Jo Besson. University Pierre et Marie Curie. Paris, FRANCE.
1999-2001: Post-PhD at NIH, Bethesda, Maryland, USA. Dir: Prof. Steven E. Hyman.
2002: 2nd Post-Ph.D at Rockefeller University, New York City. Dir: Prof. Paul Greengard.
2003-2004: Full time researcher (CR2) at INSERM. Inserm U318, Grenoble, France. Dir: Prof. Alim-Louis Benabid.
2005-2008: Full time researcher (CR1) at INSERM. Inserm U704 (Dir: Dr Marc Savasta) and then U836 (Dir: Prof. Claude Feuerstein), Grenoble, France.
2009-present : Full time researcher (CR1) at INSERM. Laboratory of CNRS UMR 5229 (Dir: Dr Jean-Rene Duhamel) in the team of Dr Leon Tremblay. Bron, France.
Physiopathology of basal ganglia; Clinical, physiopathological and pharmacological aspects of Parkinson's disease; Movement disorders; Behavioral disorders.
My research formation started in 1993 when I was in Montreal. I was studying in the lab of Dr Réjean Couture, the effects of tachykinin agonists and antagonists on a nociceptive spinal reflex in the rat. My research formation continued when I performed my master degree in Paris under the supervision of Prof Jean-Michel Deniau. During this period I studied the effects of electrical stimulation of the cerebral cortex on the expression of c-fos, an immediate early gene, in the basal ganglia on anaesthetized rat. During my PhD (September 1995 - December 1998), I did pursue the study of this experimental model to analyze molecular mechanisms (c-fos, zif268) of synaptic plasticity and signal transduction (MAP Kinases ERK, Elk-1 and CREB transcription factors) driven by electrical stimulation of the orofacial motor cortex. I then went to the NIH as a visiting fellow in the lab of Dr Steven E Hyman (director of NIMH; now Provost at Harvard) to characterize the expression and function of two new genes, ania-6 and ania-3, by molecular, cellular and biochemical approaches (1999-2002). I did perform a second post-doctoral training (2002) in the laboratory of Prof Paul Greengard (Nobel prize of medicine in 2000) at Rockefeller university in New York where I studied the role of DARPP-32 in the regulation of gene expression in response to cocaine in mice. I got an academic position at INSERM in 2002 and joined the laboratory of Prof Alim-Louis Benabid in January 2003 to investigate the phenotypic plasticity of basal ganglia neurons in response to either deep brain stimulation of the subthalamic nucleus or levodopa treatment, the two major symptomatic treatments for Parkinson’s disease, by using rodent models and combining behavioral and immunohistochemical approaches. Since 2009, I am working in the team of Dr Leon Tremblay in the laboratory of Dr Jen-Rene Duhamel, to elucidate the role of basal ganglia in the physiopathology of motor and non-motor symptoms in primates.