• E-mail :[email]
  • Phone : +33 4 77 42 14 44
  • Location : Saint-Etienne, France
Last update 2011-05-19 13:22:20.718

Luc Malaval PhD

Course and current status

Born on August the 22nd, 1955, in Alès (Gard, France). Married, two children.


Professional address

INSERM U1059-LBTO

SFR IFRESIS

Université Jean Monnet

Faculté de Médecine

15. rue A. Paré

42023 St Etienne Cedex 02

France

Telephone: 33-4-77-42-14-44, Fax: 33-4-77-57-55-72

E-mail: luc.malaval@univ-st-etienne.fr

URL: http://lbto.univ-st-etienne.fr

http://portail.univ-st-etienne.fr/73673449/0/fiche___pagelibre/

 

Degrees

Claude Bernard University-Lyon I, Lyon, France.

PhD: 1982.

Prepared in CNRS LA 244, Claude Bernard University / Lyon I. Field: Morphophysiology of invertebrate smooth muscle cells.

Previous degrees: 'Maitrise' in Animal Biology: 1977. Including certificates in Zoology, Physiology, Biochemistry and Cytology/Histology. 'Diplome d'Etudes Approfondies': 1978

'Habilitation à Diriger des Recherches' : 2001

 

Scientific interests

Osteoblastogenesis and bone formation: regulation by matrix proteins and mechanical factors.

 

Career curriculum

  • 1983 to 1986 : Research scientist in the "Centre de recherche en Rhumatologie", Edouard Herriot hospital, Lyon, France. Validation of the radioimmunoassay of circulating osteocalcin as a marker of bone remodeling.

  • 1986 to 1991 : Staff scientist ('Chargé de Recherches') in INSERM Unit 234, "Pathologie des tissus calcifiés", Edouard Herriot hospital, Lyon, France, directed by Pr Pierre J Meunier. Development and validation of radioimmunoassays for SPARC/osteonectin - exploration of its intertissular variability and potential use as a marker.

  • 1991 to 1993 : Visiting scientist in the "Medical Research Council Group in Periodontal Physiology", University of Toronto, Toronto, Ontario, Canada, working in Dr Jane E Aubin's laboratory. Study of the expression of bone related proteins during the differentiation of the osteoblast phenotype in in vitro models of osteogenesis.

  • 1993 to 2003 : Staff scientist in INSERM Unit 403 "Physiopathologie des ostéopathies fragilisantes", Edouard Herriot Hospital, Lyon, France, directed by Pr Pierre D Delmas. Recruitement and differentiation of osteoprogenitors – regulation by matrix proteins and cytokines. In vitro models of osteogenesis.

  • Present position (since 2004) : Staff scientist in LBTO-INSERM U890, « Tissus osseux et contraintes mécaniques », Faculté de Médecine, Université Jean Monnet, St Etienne, France, directed by Dr Laurence Vico.

 

Student supervision

16 graduate students, 12 post-graduates, including 6 PhDs (4 defended, in october 1998, april 2008 and 2 in december 2009 ; 2 in course). 2 Post-docs (2008-2009 and 2011-).

 

Meeting organization

Member of the organizing committees of the first "Journées Françaises de Biologie des Tissus Minéralisés", Lyon (January 22-23, 1998), the 9th (Lyon, 2006) and the 12th (Saint-Etienne, 2010) – Treasurer of the organizing society (1998-2000).

 

Fellowships and awards

1978: Claude Bernard University Studentship

1985, 1991: Fellowships from the "Fondation pour la Recherche Médicale"

1991: NATO Science Fellowship

1992, 1997: INSERM/MRC (Canada) Exchange Awards

1995, 1997: Fellowships from the "Centre Jacques Cartier"

 

Grant funding

1995 and 1998: NATO Collaborative Research grants (Lyon/Toronto)

1998: Grant from the CNRS/INSERM “Cell/Substrate adhesion” program

2001: «Research Quality Bonus» grant from Université Claude Bernard - Lyon I

2001: Grant from the Rhône-Alpes Region “Emergence” program

2002: Grant within the “Developmental Biology and Integrative Physiology Concerted Incentive Action” of the Ministry for Research.

2004: Grant within the CNRS/INSERM “ Tissue Engineering – Biomecanics - Biomaterials ” (IT2B) joint program

2009: «Research Quality Bonus» grant from the Université Jean Monnet – Saint-Etienne

2010: Grant from the Rhône-Alpes Region “Cible” program

2010: Research grant from the “Société Française de Rhumatologie”

Memberships

« Société Françaises de Biologie des Tissus Minéralisés »

« Société Française de Rhumatologie »

American Society for Bone and Mineral Research

European Calcified Tissue Society

Scientific summary

Research Theme:

Integration of mechanical signals by osteoblasts and their matrix - differentiation, phenotype.

Main topics:

1/ Analysis of the phenotype of mice with a KO of Bone Sialoprotein (BSP), a major component of mineralized extracellular matrices. Through repair models (artificial fracture), unloading (tail suspension), ovariectomy, mechanical stimulation as well as in vitro osteogenesis and osteoclastogenesis, we analyze the consequences of the lack of BSP on the baseline mechanical competence of the skeleton, as well as its response to challenges.

2/ Study of the mechanisms through which mechanical stress regulates the differentiation of osteoblasts and bone formation, with a special interest for the role of the extracellular matrix, and specifically BSP, in 3D perfused models of in vitro osteogenesis.

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