2010-present: Directeur de Recherche II INSERM, Cancer Research Center of Marseille, Immunology department, head of the Lymphocyte Activation Group, Marseille
2001-2010: Chargé de Recherche I INSERM, INSERM UMR 599/891 : Centre de Recherche en Cancerologie de Marseille, Immunology department, head of the Lymphocyte Activation Group, Marseille
1997-2001: Chargé de Recherche II INSERM, INSERM U119, Molecular and Functional Immunology Laboratory (head : Daniel Olive), Marseille.
1996-97: Post-doctoral fellow, Centre d'Immunologie INSERM-CNRS de Marseille-Luminy (CIML), Interactions lymphocytaires Laboratory (head : Bernard Malissen), Marseille, France.
1993-95: Post-doctoral fellow, Imperial Cancer Research Fund, Lymphocyte Activation Laboratory (head : Doreen A. Cantrell), London, UK.
1998: National Diploma "Habilitation à Diriger des Recherches", University Aix-Marseille II.
1992: Ph. D., University Aix-Marseille II.
We are involved in:
analyzing cell signaling events in lymphocytes to identify the driving force of those cells for controling antitumoral responses,
dissecting cell signaling events in cancer cells to improve chemotherapy.
Signal transduction studies correspond to a major investigation field for dissecting the mechanisms involved in the regulation of cellular functions. In T cells, our work focuses on the activation of a specific signaling pathway which turns-on upon T Cell Receptor (TCR) and costimulatory molecules triggering : the phosphatidyl-inositol 3’-kinase (PI-3K) signaling pathway (for review Okkenhaug K. and Vanhaesebroeck B., Nat. Rev. Immnuol. 2003). This PI-3K pathway has also a role in many tumor cells (for review Vivanco I. and Sawyers C.L., Nat. Rev. Cancer 2002).