• E-mail :[email]
  • Phone : 0149814795
  • Location : Paris, France
Last update 2011-06-02 12:07:41.691

Martin Higgs PhD Virology

Course and current status

Post-Doctoral Fellow: 2008 - Present

French National Institute for Health and Medical Research (INSERM) U955, Créteil, France

"Investigating the molecular mechanisms of hepatocellular carcinoma in HCV-infected individuals"

  • Using in vivo and in vitro models of HCV infection to investigate the molecular mechanisms of liver tumourigenesis.
  • Expression analyses (qPCR, immunoblotting, 2D-DIGE), promoter methylation studies, reporter assays, siRNA studies, immunofluorescence, tumoural analyses.
  • Project conception, finance and planning, data keeping, implementation of individual research.
  • Creation and maintenance of international collaborations.
  • Grant writing: securing funding for both projects and equipment. Negotiation of prices and discounts with suppliers.
  • Presentation of data at national and international seminars and meetings.
  • Supervision of undergraduate and postgraduate students within laboratory. Design, development and supervision of individual projects.

PhD2003 - 2008

Medical Research Council (MRC) Virology Unit and University of Glasgow, Glasgow, UK

"The role of the herpes simplex virus type 1 UL33 protein in DNA packaging"

  • Generation of panels of mutants and subsequent analysis: immunoprecipitation, immunofluorescence, DNA packaging and viral replication assays.
  • Maintenance of lab records, project management, logical planning and implementation of individual research.
  • Critical appraisal of scientific literature; thesis writing.
  • Presentation of data at seminars, conferences and meetings.
  • Supervision of postgraduate colleagues within laboratory.

Research Technician: 2003 - 2004

University of Leeds, Leeds, UK

  • Cloning and expression of fusion proteins of GBVB p13 gene.
  • Sequencing of HCV-infected patient isolates using RT-PCR.
  • Maintenance of lab records, presentation of data, planning individual research.

Scientific summary

I am particularly interested in the effects of chronic viral infection on the development and acceleration of tumourigenesis.

My experiences during post-graduate and post-doctoral research have reinforced my ultimate ambition to direct a research group

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