jean-philippe empana MD PhD
Course and current status
Position
Since 2006, Full time researcher at INSERM (fixed position)
Currently INSERM Research Director (DR2) and co-director of Team 4 "Integrative Epidemiology of Cardiovascular Disease" at the Paris Cardiovascular Research Centre, INSERM U970
Diploma
2009 HDR (Hability to Direct Research), Paris, France
2005 PhD degree in Epidemiology and Public Health, Paris
1996-2001 Internship in Public Health, Lille, France
1988-1995 Studies of Medicine, Lyon, France
Teams:
Sept 2009- INSERM U970, team 4 "Integrative Epidemiology of Cardiovascular Disease"
2007-2009 INSERM U909
2002-2007 INSERM AVENIR team, Paris
Scientific summary
I am co-directing with X Jouven, a 45 staff members multidisciplinary team dedicated to the epidemiology of cardiovascular disease and its complications. A total of 4 research topics are addressed and include 1) the epidemiology of cardiac arrest; 2) the place of novel biomarkers for CVD risk prediction; 3) the epidemiology of CVD in sub saharian african countries; and 4) the determinants of antibody mediated rejection in heart transplant.
More specifically, I am coordinating the Paris Prospective study III, a prospective cohort study that has included 10 166 participants who have been followed up every two years for 12 years now. We are interested in the predictive power of heart rate parameters (2h of recordings), carotid artery stiffness parameters and measures of the baroreflex sensitivity (carotid echotracking) together with novel circulating blood biomarkers (a large biobank of 200 000 baseline samples is available) for primarily incident CVD events.
I am also leading a collaborative and international research programme on the clinical relevance of a novel concept of prevention of CVD, i.e. primordial prevention. This approach aims to prevent the onset of risk factors of CVD in the first place. We have recently demonstrated the relevance of this approach for CVD and non CVD outcomes including dementia, T2D, cancer, or depression asuggesting that this concept may be helpful for a global prevention of chronic diseases. This is well supported by our crecent publication showing association with multimorbidty risk. This project is developped though several national and international collaborations including the Three City Study (France), the Whitehall II study (UK), the Maastricht study (the Netherlands) and the CoLaus study (Switzerland).
Since 2021 and for the next 3 years, I have been appointed as chair on Global Health at Université Paris Cité in the context of the European Circle U alliance comprising 8 European universities (Paris, La Charité Berlin; Aarhus, Danemark; King's College, Londres; Pise, Italie; Vienne, Autriche; Oslo, Suède; Belgrade, Serbie). I am now the Acdemic Director of the Knowledge Hub on Global Health. In particular, we are preparing a joint Master-PhD programme across the 9 Circle U universities.
With X Jouven, we are partners and WP leaders of a H2020 programme (ESCAPENET) on the epidemiology of cardiac arrest in 16 European countries. A COST Action programme we are members of is now following the ESCAPENET programme and aims to establish an international network on the prevention and management of cardiac arrest. I used to be an active member of the Paris Transplant Group led by A Loupy, which aims to assess the patterns and determinants of acyte rejection of solid organ transplants.
