Jean-Marie Zajac Ph.D. molecular and cellular biology

Course and current status

Ph.D. molecular and cellular biology , 1979

Doctorat d'Etat ès Sciences Naturelles, P. et M. Curie University, Paris, 1989

             Professional experience 

1983 Senior Scientist CNRS, Laboratoire Pharmacochimie Moléculaire INSERM, CNRS, Paris

1989 Laboratoire de Pharmacologie et de Toxicologie Fondamentales, UPR CNRS, Toulouse

1994-1995 Sanofi-Recherche

1996 Institut de pharmacologie et de Biologie Structurale, UPR 9062 CNRS, Toulouse 


________Current Position

Director of Research, CNRS, team leader, Institut de pharmacologie et de Biologie Structurale, Toulouse 

Scientific summary

Molecular and functional pharmacology of neuropeptide receptors

Our team is devoted to the biochemical, cellular and pharmacological characterization of Neuropeptide FF (NPFF, FLFQPQRFamide), a neuromodulator of the central nervous system, which has been identified as an anti-opioid peptide. Several pharmacological data suggest that NPFF plays an important role in pain modulation and acts mainly through the regulation of the opioid system. The elucidation of the mechanisms underlying such effects is essential to our understanding of pain perception and opiate addiction.

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