CV Science

Lionel Mourey PhD Structural biology

Course and current status

Lionel MOUREY – CURRICULUM VITAE – Sept. 2011

Family name: MOUREY

Given name: Lionel

Nationality: French

Date of birth: 5 August 1961

Place of birth: Vesoul, France

Marital status: Married, 2 children

Current position: CNRS tenured senior researcher

Institut de Pharmacologie et de Biologie Structurale, CNRS – Université de Toulouse

Address: IPBS, 205 route de Narbonne, BP 64182, 31077 Toulouse, France

Tel.: (33) 5 61 17 54 36, Fax: (33) 5 61 17 59 94

Email: Lionel.Mourey@ipbs.fr

EDUCATION

- 2002: Habilitation à Diriger des Recherches (HDR), University of Toulouse

- 1991: PhD from the University of Strasbourg, Dr D. Moras, Institut de Biologie Moléculaire et Cellulaire (IBMC), Strasbourg, France

- 1988: DEA (master's degree) of biological crystallography, University of Strasbourg

- 1984-87: Engineer diploma, Ecole Nationale Supérieure de Chimie, Strasbourg

PROFESSIONNAL APPOINTMENTS

- Since 2009: Joint director of the Structural Biology and Biophysics department, IPBS, Toulouse

- Since 2006: Scientific supervisor of the Integrated Screening Platform of Toulouse (PICT-IBiSA)

- 2005: CNRS senior researcher

- Since 2002: Head of the structural biophysics team and of the macromolecular crystallographic facility, IPBS, Toulouse

- 1992-2001: CNRS Researcher, Laboratory of Crystallography, Dr J.-P. Samama, IPBS, Toulouse

- 1991-92: Post doctoral fellow of Dr D. Moras, IBMC, Strasbourg

KEYWORDS

X-ray scattering and diffraction; biocrystallography; structural biology, microbiology, immunology, and pharmacology; proteins-ligands interactions; structure-based ligands screening and design

Scientific summary

The main objectives of the Institute of Pharmacology and Structural Biology (IPBS) are to characterize fundamental mechanisms that control the function of biological systems in order to develop pharmacological applications. With that respect, our team has developed and currently maintain a cutting edge centre in biochemistry, biophysics and bio-crystallography.  Our expertise covers the different steps required for determining crystal structures of biological macromolecules and understanding their structure-function relationships: production and purification of recombinant proteins, characterization in solution and crystallization of proteins and their complexes (protein-protein, protein-DNA, protein-ligands), X-ray scattering and diffraction studies, 3D structure determination and analysis. We put our expertise and equipment at the disposal of the scientific community through a crystallographic facility, which is part of the interdisciplinary Integrated Screening Platform of Toulouse (PICT-IBiSA).

Research interests: fight against mycobacterial diseases, characterization of new protein families, enzymes for biotechnological applications, bacterial pore-forming toxins, methodological developments.