Christophe Guilhot PhD Microbiology

Course and current status

GUILHOT, Christophe

Institut de Pharmacologie et de Biologie Structurale (IPBS), Centre National de la Recherche Scientifique (CNRS), 205 route de Narbonne, 31077 Toulouse cedex 04.

Email :

Positions Held and Research Activities :

 2009-2015: Co-Director of the Department “Molecular Mecanisms of Mycobacterial Infections” at the IPBS (Toulouse), Member of the Direction Comitee of IPBS.

2005-present: Director of Research at the CNRS.

2000-present: Head of the Research Team "Molecular Mycobacterial Pathogenesis” at the IPBS (Toulouse), 6-8 people working on the characterization of the role of cell envelope lipids in the pathogenicity of mycobacteria.

2001-2005: Associate Professor at the CNRS

1996-2000: Associate Professor at the Institut Pasteur (Paris) in the “Unité de Genetique Mycobacterienne” headed by Prof. B. Gicquel. Leader of a group of 3 people carrying out genetic screening to identify virulence factors of Mycobacterium tuberculosis.

1994-1995: Post-Doctoral Fellow at Harvard Medical School (Boston), Dept. Microbiology and Molecular Genetics (Team of Prof. J. Beckwith). Study of protein folding in the periplasm of Escherichia coli.

1990-1994: Ph-D Student at the Institut Pasteur (Paris) under the supervision of Prof. B. Gicquel. Development of molecular tools for the genetic engineering of mycobacteria. Some of these tools are still used worldwide for insertional mutagenesis of mycobacteria.



2001 : Habilitation à Diriger des Recherches (Université Paris 7, René Descartes, France)

1994 : Ph.D Microbiology (Université Paris 7, René Descartes, France)

1989 : Masters Degree in Enzymatic Engineering, Bioconversion, Microbiology (Université de Technologie de Compiègne, France)

1989 : Engineering Diploma, Ecole Nationale Supérieure des Industries Agroalimentaires, France)

Track Records :

*     54 publications in peer-reviewed journals and 8 book chapters

*     5 patents

Scientific summary

I am a microbiologist and molecular geneticist with a long standing interest in bacterial pathogenicity. Over the last 20 years, I have developed a strong expertise in the genetic engineering of mycobacteria, including Mycobacterium tuberculosis, the causative agent of human tuberculosis. I pionnered the work on the molecular mechanisms of action of mycobacterial lipids during host/pathogen interaction. In 2000, I received an ATIP award from the CNRS to develop specific projects on this topic.

In the last 20 years, I published more than 50 articles in this field.

Since 2000, I have lead a team a the Institut de Pharmacologie et Biologie Structurale (IPBS) in Toulouse. I was member of the IPBS executive committee and head of the "Tuberculosis & Infection Biology" Department from 2009 to 2015. I was member of the Editor Board  of the Journal of Biological Chemistry from 2008 to 2013 and I have been Section Editor at Tuberculosis since 2012.

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