CV Science

Matthieu FONVIELLE Synthesis of inhibitors for the study of new therapeutic targets

Course and current status

2016 HDR of Chemistry from Paris V University
Synthesis of inhibitors for the study of new therapeutic targets

2016 INSERM Chargé de recherche (CR1) LRMA, Team 12 UMRS 1138

2013 INSERM Chargé de recherche (CR2) LRMA, Team 12 UMRS 1138

2012 - 2013 Post-doctorate CNRS, UMR 8601
Prof. Mélanie Ethève-Quelquejeu
Synthesis of beta-lactams for the inhibition of Mycobacterium tuberculosis.

2010 - 2012 Post-doctorate, INSERM, U655
Dr Michel Arthur
Studies on cyclodipeptide synthases (CDPS), a new family of enzymes using aminoacylated tRNA to form peptide bonds.

2008 - 2010 Post-Doctorate, CEA, Direction des Sciences du Vivant, Service d'Ingénierie Moléculaire des Protéines (SIMOPRO)
Dr Pascal Belin
Design, synthesis and evaluation of inhibitors of CYP121, a cytochrome P450 essential for the survival of Mycobacterium tuberculosis.

2006 - 2008 Post-Doctorate, INSERM, U655
Dr Michel Arthur
Synthesis of tRNA analogues to study the substrate specificity of FemXWv, an amino-acyl transferase of the Fem family from Weissella viridescens.

2003 - 2006 PhD in Organic Chemistry, University of Paris XI, UMR 8124
Supervisor: Prof. Michel Thérisod
Synthesis and evaluation of new selective inhibitors of fructose-1,6-bisphosphate aldolase class II: towards new synthetic antibiotics.

Scientific summary

As a PhD student, I worked at the University of Paris 11 in the team of Professor Michel THERISOD. My project concerned the synthesis and in vitro evaluation of zinc-dependent inhibitors of fructose-1,6-bisphosphate aldolase class II of pathogenic bacteria.
After my PhD, I joined Michel Arthur's INSERM group in Paris for a first post-doctoral position where I worked on the amino acyl tRNA dependent enzymes, the Fem transferases. During this post-doc, I synthesized a first family of stable amionoacyl-tRNA analogues inhibiting FemX from Weissella viridescens. In 2008 I joined Dr Muriel Gondry's team at CEA where I worked on the synthesis of inhibitors of an essential cytochrome P450 of Mycobacterium tuberculosis (CYP121). In 2010, I came back to Michel Arthur's team for a second postdoctoral fellowship where I worked on the synthesis of inhibitors of peptidyl-RNA bi-substrates. In 2012, I joined the team of Professor M. Ethève-Quelquejeu (University of Paris 5); my project was on the synthesis of modified carbapenems. In 2013, I was recruited by INSERM as a research fellow in Michel Arthur's team where I started to study RNAt-dependent aminoacyltransferases Fem of Gram-positive pathogenic bacteria (Staphylococcus aureus). In parallel, I also developed strategies to obtain synthetic analogues of peptidoglycan precursors by solid phase or semi-synthesis.  I have a broad experience in chemistry, biochemistry and structural biology, with an expertise in the semi-synthesis of bi-substrate inhibitors containing complex macromolecules such as peptides or RNA fragments.

Full list of work published in ResearcherID:
http://www.researcherid.com/rid/ G-5644-2015