CV Science

Servane Tauszig-Delamasure PhD Cellular and molecular biology

Course and current status

EDUCATION

>1998-2003 : Master degree and PhD Molecular and Cellular Biology –Univ.L.Pasteur, Strasbourg, France

>1998 : Master of science Engineer diploma – UTC Compiègne, France

>1995-1996 : Engineering bachelor degree (ERASMUS European program), Tech. Univ. Berlin, Germany

EXPERIENCE

> 2016-date : Research director CNRS (French National Center for Scientific Research), in Dr. V. Castellani’s lab, Institut NeuroMyoGene, Lyon, France 

Project manager : “Modeling Medulloblastoma in the chick embryo : impact of neurodevelopmental signals from the microenvironnement on tumor progression and metastatic dissemination”

> 2004-2015 : Researcher in the team led by Dr. P. Mehlen, Cancer Research Center (CRCL), Lyon, France

Project manager : “Tumoral escape - Tyrosine kinase dependence receptors apoptotic function”

> 2003-2004 : Post-doctoral fellow –RET apoptotic function in enteric nervous system development.  Dr. P. Mehlen - CGMC, Villeurbanne. France

> 2003 : University College London, Institute of Child Health, London, UK. Pr. A. Burns (Collaboration – 3 months)

> 1998-2003 : PhD– Drosophila innate immunity (Toll receptors). IBMC, CNRS UPR9022, Strasbourg. France. Pr. J. Hoffmann - PhD supervisor : Pr. JL Imler

> 2002 : Department of Pediatrics, Laboratory of Developmental Immunology

Massachusetts General Hospital, Harvard Medical School, Boston, USA - Pr. Alan Ezekowitz (Collaboration - 4 months)

CURRENT POSITION

I am a research director working for the French national scientific research center (CNRS) in Lyon, France. I have worked for many years on cancer and particularly on pediatric cancers. In 2016, I joined the team led by Valérie Castellani at the INMG Institute who studies the mechanisms of embryonic neural development and their deregulations in childhood malignancies. I have recently started a new project on medulloblastoma. This cancer indeed derives from alterations occurring during cerebellum development.

Scientific summary

We have developed a new model of medulloblastoma in the chick embryo. This model allows to have a visual and experimental access to the developing embryo.  Fluorescent medulloblastoma cells are grafted in the cerebellum primordium. Clearing technics are combined with 3D light sheet confocal imaging and allow to observe tumor formation and leptomeningeal dissemination. We demonstrate that medulloblastoma cells exploit at their advantage embryonic neurodevelopmental pathways during tumor progression.