johanna lepeule
  • E-mail :[email]
  • Phone : +33476549466
  • Location : grenoble, France
Last update 2023-11-01 22:38:21.037

johanna lepeule Environmental epidemiologist, PhD

Course and current status

Current position 

Researcher, INSERM U1209, IAB (Intsitute for Advanced Biosciences), Team EDES (Environmental Epidemiology Applied to Development and Respiratory Health)

Major research interests

Effects of early exposure to environmental factors related to the urban exposome (ie. air pollutants, weather conditions), on the health of the mother and development of the child. 

Epigenetic marks as potential biomarkers or mediators of the health effects of environmental exposures.  


2021HDR, Environmental epidemiology - University of Grenoble

2007Ph.D, Veterinary epidemiology - University of Rennes 1

2004M.S., Biostatistics - University of Paris-Sud 11 

2003M.S., Public health - University of Bordeaux

2001B.S., Statistics, informatics - University of Grenoble


2013-now - Researcher, INSERM, Environmental epidemiology, Grenoble, France

2013-15 - Visiting Scientist, Harvard School of Public Health, Environmental health, Boston, USA  

2010-13 - Postdoctoral fellow, Harvard School of Public Health, Environmental health, Boston, USA  

2008-10 - Postdoctoral fellow, INSERM, Environmental epidemiology, Grenoble, France

2007-08 - Research assistantINRA - Veterinary school Veterinary epidemiology, Nantes, France

2004-07 - PhD student, INRA - Veterinary school, Veterinary epidemiology  Nantes, France

2004      Master studentINSERM, Biostatistics, Bordeaux, France

2002-04 - Research assistant, ISPED, Occupational health, Bordeaux, France

 National Institute for Health and Medical Research (INSERM U1290), Grenoble, Team of Environmental Epidemiology applied to Development and Respiratory health


Scientific summary

Nakamura A, Broséus L, Tost J, Vaiman D, Martins S, Keyes K, Bonello K, Fekom M, Strandberg-Larsen K, Sutter-Dallay AL, Heude B, Melchior M, Lepeule J. Epigenome-Wide Associations of Placental DNA Methylation and Behavioral and Emotional Difficulties in Children at 3 Years of Age. Int J Mol Sci. 2023 Jul 21;24(14):11772.

Jumentier B, Barrot CC, Estavoyer M, Tost J, Heude B, François O, Lepeule J. High-Dimensional Mediation Analysis: A New Method Applied to Maternal Smoking, Placental DNA Methylation, and Birth Outcomes. 2023. Environ Health Perspect. Apr;131(4):47011. 

Guilbert A, Bernard JY, Peyre H, Costet N, Hough I, Seyve E, Monfort C, Philippat C, Slama R, Kloog I, Chevrier C, Heude B, Ramus F, Lepeule J. Prenatal and childhood exposure to ambient air pollution and cognitive function in school-age children: Examining sensitive windows and sex-specific associations. Environ Res. 2023 Oct 15;235:116557.

Guilbert A, Hough I, Seyve E, Rolland M, Quentin J, Slama R, Lyon-Caen S, Kloog I, Bayat S, Siroux V, Lepeule J. Association of Prenatal and Postnatal Exposures to Warm or Cold Air Temperatures With Lung Function in Young Infants. 2023. JAMA Netw Open. Mar 1;6(3):e233376.

Lepeule J, Pin I, Boudier A, Quentin J, Lyon-Caen S, Supernant K, Seyve E, Chartier R, Slama R, Siroux V; SEPAGES study group. Pre-natal exposure to NO2 and PM2.5 and newborn lung function: An approach based on repeated personal exposure measurements. Environ Res. 2023 Jun 1;226:115656.

Hough I, Rolland M, Guilbert A, Seyve E, Heude B, Slama R, Lyon-Caen S, Pin I, Chevrier C, Kloog I, Lepeule J. Early delivery following chronic and acute ambient temperature exposure: a comprehensive survival approach. Int J Epidemiol. 2023 Jun 6;52(3):761-773.

Broséus L, Vaiman D, Tost J, Martin CRS, Jacobi M, Schwartz JD, Béranger R, Slama R, Heude B, Lepeule J. Maternal blood pressure associates with placental DNA methylation both directly and through alterations in cell-type composition. 2022. BMC Med. Oct 20;20(1):397.

Jedynak P, Tost J, Calafat AM, Bourova-Flin E, Busato F, Forhan A, Heude B, Jakobi M, Rousseaux S, Schwartz J, Slama R, Vaiman D, Philippat C, Lepeule J. Pregnancy exposure to synthetic phenols and placental DNA methylation - An epigenome-wide association study in male infants from the EDEN cohort. Environ Pollut. 2021 Dec 1;290:118024.

Hough I, Sarafian R, Shtein A, Zhou B, Lepeule J*, Kloog I*. Gaussian Markov random fields improve ensemble predictions of daily 1 km PM2.5 and PM10 across France. 2021. Atmos Env. Nov;264:118693.

Jakpor O, Chevrier C, Kloog I, Benmerad M, Giorgis-Allemand L, Cordier S, Seyve E, Vicedo-Cabrera AM, Slama R, Heude B, Schwartz J, Lepeule J. Term birthweight and critical windows of prenatal exposure to average meteorological conditions and meteorological variability. Environ Int. 2020 Sep;142:105847.

Everson T*, Vives-Usano M*, Seyve E*, Cardenas A, Lacasaña M, Craig J, Lesseur C, Baker E, Fernandez-Jimenez N, Heude B, Perron H, Gónzalez-Alzaga B, Halliday J, Deyssenroth M, Karagas M, Íñiguez C, Bouchard L, Carmona-Sáez P, Loke Y, Hao K, Belmonte T, Charles MA, Martorell-Marugán J, Muggli E, Chen J, Fernández M, Tost J, Gómez-Martín A, London S, Sunyer J, Marsit C*, Lepeule J*, Hivert MF*, Bustamante M*. Placental DNA methylation signatures of maternal smoking during pregnancy and potential impacts on fetal growth. 2021. Nat Commun. Aug 24;12(1):5095.

Hough I, Just AC, Zhou B, Dorman M, Lepeule J, Kloog I. A multi-resolution air temperature model for France from MODIS and Landsat thermal data. 2020. Environ Res. Apr;183:109244.

Rousseaux S, Seyve E, Chuffart F, Bourova-Flin E, Benmerad M, Charles MA, Forhan A, Heude B, Siroux V, Slama R, Tost J, Vaiman D, Khochbin S, Lepeule J. Immediate and durable effects of maternal tobacco consumption alter placental DNA methylation in enhancer and imprinted gene-containing regions. 2020. BMC Med. Oct 7;18(1):306.

Abraham E, Rousseaux S, Agier L, Giorgis-Allemand L, Tost J, Galineau J, Hulin A, Siroux V, Vaiman D, Charles MA, Heude B, Forhan A, Schwartz J, Chuffart F, Bourova-Flin E, Khochbin S, Slama R, Lepeule J; Pregnancy exposure to atmospheric pollution and meteorological conditions and placental DNA methylation. Environ Int. 2018 Sep;118:334-347.

Lepeule J, Bind MA, Baccarelli AA, Koutrakis P, Tarantini L, Litonjua A, Sparrow D, Vokonas P, Schwartz JD. Epigenetic influences on associations between air pollutants and lung function in elderly men: the normative aging study. Environ Health Perspect. 2014 Jun;122(6):566-72.

Lepeule J, Laden F, Dockery D, Schwartz J. Chronic Exposure to Fine Particles and Mortality: An Extended Follow-up of the Harvard Six Cities Study from 1974 to 2009. 2012. Environ Health Perspect. Jul;120(7):965-70.

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