CV Science

johanna lepeule Environmental epidemiologist, PhD

Course and current status

2024-now - Director of Research, INSERM, Environmental epidemiology, Grenoble, France

2013-2024 - Researcher, INSERM, Environmental epidemiology, Grenoble, France

2013-15 - Visiting Scientist, Harvard School of Public Health, Environmental health, Boston, USA  

2010-13 - Postdoctoral fellow, Harvard School of Public Health, Environmental health, Boston, USA  

2008-10 - Postdoctoral fellow, INSERM, Environmental epidemiology, Grenoble, France

2007-08 - Research assistant, INRA - Veterinary school Veterinary epidemiology, Nantes, France

2004-07 - PhD student, INRA - Veterinary school, Veterinary epidemiology  Nantes, France

2004      - Master student, INSERM, Biostatistics, Bordeaux, France

2002-04 - Research assistant, ISPED, Occupational health, Bordeaux, France

Scientific summary

Barbalat G, Guilbert A, Adelaïde L, Charles MA, Hough I, Launay L, Kloog I, Lepeule J. Impact of early life exposure to heat and cold on linguistic development in two-year-old children: findings from the ELFE cohort study. Environ Health. 2025 Apr 9;24(1):19. https://doi.org/10.1186/s12940-025-01173-8

Adélaïde L, Nakamura A, Guilbert A, Vandentorren S, Stempfelet M, Hough I, Seyve E, Launoy G, Launay L, Charles MA, Chevrier C, Monfort C, Heude B, Tafflet M, Bayat S, Kloog I, Lepeule J*, Pascal M*. Exploring heat risk in pregnant women: do environmental and social inequalities amplify heat exposure? Int J Biometeorol. 2025 Jun;69(6):1347-1362. https://doi.org/10.1007/s00484-025-02895-7

Barbalat G, Hough I, Dorman M, Lepeule J*, Kloog I*. A multi-resolution ensemble model of three decision-tree-based algorithms to predict daily NO2 concentration in France 2005-2022. Environ Res. 2024 Sep 15;257:119241. https://doi.org/10.1016/j.envres.2024.119241

Broséus L, Guilbert A, Hough I, Kloog I, Chauvaud A, Seyve E, Vaiman D, Heude B, ChevrierC, Tost J, Slama R, Lepeule J. Placental DNA methylation signatures of prenatal airpollution exposure and potential effects on birth outcomes: an analysis of three prospectivecohorts. Lancet Planet Health. 2024 May;8(5):e297-e308. https://doi.org/10.1016/S2542-5196(24)00045-7

Adélaïde L, Hough I, Seyve E, Kloog I, Fifre G, Launoy G, Launay L, Pascal M*, Lepeule J*. Environmental and social inequities in continental France: an analysis of exposure to heat, air pollution, and lack of vegetation. J Expo Sci Environ Epidemiol. 2024 Nov;34(6):962-972. https://doi.org/10.1038/s41370-024-00641-6  

Nakamura A, Broséus L, Tost J, Vaiman D, Martins S, Keyes K, Bonello K, Fekom M, Strandberg-Larsen K, Sutter-Dallay AL, Heude B, Melchior M, Lepeule J. Epigenome-Wide Associations of Placental DNA Methylation and Behavioral and Emotional Difficulties in Children at 3 Years of Age. Int J Mol Sci. 2023 Jul 21;24(14):11772. https://doi.org/10.3390/ijms241411772

Jumentier B, Barrot CC, Estavoyer M, Tost J, Heude B, François O*, Lepeule J*. High-Dimensional Mediation Analysis: A New Method Applied to Maternal Smoking, Placental DNA Methylation, and Birth Outcomes. 2023. Environ Health Perspect. Apr;131(4):47011. https://doi.org/10.1289/EHP11559 

Guilbert A, Bernard JY, Peyre H, Costet N, Hough I, Seyve E, Monfort C, Philippat C, Slama R, Kloog I, Chevrier C, Heude B, Ramus F, Lepeule J. Prenatal and childhood exposure to ambient air pollution and cognitive function in school-age children: Examining sensitive windows and sex-specific associations. Environ Res. 2023 Oct 15;235:116557. https://doi.org/10.1016/j.envres.2023.116557 

Guilbert A, Hough I, Seyve E, Rolland M, Quentin J, Slama R, Lyon-Caen S, Kloog I, Bayat S, Siroux V, Lepeule J. Association of Prenatal and Postnatal Exposures to Warm or Cold Air Temperatures With Lung Function in Young Infants. 2023. JAMA Netw Open. Mar 1;6(3):e233376. https://doi.org/10.1001/jamanetworkopen.2023.3376

Lepeule J, Pin I, Boudier A, Quentin J, Lyon-Caen S, Supernant K, Seyve E, Chartier R, Slama R, Siroux V; SEPAGES study group. Pre-natal exposure to NO₂ and PM_2.5 and newborn lung function: An approach based on repeated personal exposure measurements. Environ Res. 2023 Jun 1;226:115656. https://doi.org/10.1016/j.envres.2023.115656

Hough I, Rolland M, Guilbert A, Seyve E, Heude B, Slama R, Lyon-Caen S, Pin I, Chevrier C, Kloog I, Lepeule J. Early delivery following chronic and acute ambient temperature exposure: a comprehensive survival approach. Int J Epidemiol. 2023 Jun 6;52(3):761-773. https://doi.org/10.1093/ije/dyac190

Broséus L, Vaiman D, Tost J, Martin CRS, Jacobi M, Schwartz JD, Béranger R, Slama R, Heude B, Lepeule J. Maternal blood pressure associates with placental DNA methylation both directly and through alterations in cell-type composition. 2022. BMC Med. Oct 20;20(1):397. https://doi.org/10.1186/s12916-022-02610-y

Hough I, Sarafian R, Shtein A, Zhou B, Lepeule J*, Kloog I*. Gaussian Markov random fields improve ensemble predictions of daily 1 km PM_2.5 and PM₁₀ across France. 2021. Atmos Env. Nov;264:118693. https://doi.org/10.1016/j.atmosenv.2021.118693

Jakpor O, Chevrier C, Kloog I, Benmerad M, Giorgis-Allemand L, Cordier S, Seyve E, Vicedo-Cabrera AM, Slama R, Heude B, Schwartz J, Lepeule J. Term birthweight and critical windows of prenatal exposure to average meteorological conditions and meteorological variability. Environ Int. 2020 Sep;142:105847. https://doi.org/10.1016/j.envint.2020.105847

Everson T*, Vives-Usano M*, Seyve E*, Cardenas A, Lacasaña M, Craig J, Lesseur C, Baker E, Fernandez-Jimenez N, Heude B, Perron H, Gónzalez-Alzaga B, Halliday J, Deyssenroth M, Karagas M, Íñiguez C, Bouchard L, Carmona-Sáez P, Loke Y, Hao K, Belmonte T, Charles MA, Martorell-Marugán J, Muggli E, Chen J, Fernández M, Tost J, Gómez-Martín A, London S, Sunyer J, Marsit C*, Lepeule J*, Hivert MF*, Bustamante M*. Placental DNA methylation signatures of maternal smoking during pregnancy and potential impacts on fetal growth. 2021. Nat Commun. Aug 24;12(1):5095. https://doi.org/10.1038/s41467-021-24558-y

Hough I, Just AC, Zhou B, Dorman M, Lepeule J, Kloog I. A multi-resolution air temperature model for France from MODIS and Landsat thermal data. 2020. Environ Res. Apr;183:109244. https://doi.org/10.1016/j.envres.2020.109244

Rousseaux S, Seyve E, Chuffart F, Bourova-Flin E, Benmerad M, Charles MA, Forhan A, Heude B, Siroux V, Slama R, Tost J, Vaiman D, Khochbin S, Lepeule J. Immediate and durable effects of maternal tobacco consumption alter placental DNA methylation in enhancer and imprinted gene-containing regions. 2020. BMC Med. Oct 7;18(1):306. https://doi.org/10.1186/s12916-020-01736-1

Abraham E, Rousseaux S, Agier L, Giorgis-Allemand L, Tost J, Galineau J, Hulin A, Siroux V, Vaiman D, Charles MA, Heude B, Forhan A, Schwartz J, Chuffart F, Bourova-Flin E, Khochbin S, Slama R, Lepeule J; Pregnancy exposure to atmospheric pollution and meteorological conditions and placental DNA methylation. Environ Int. 2018 Sep;118:334-347. https://doi.org/10.1016/j.envint.2018.05.007

Lepeule J, Bind MA, Baccarelli AA, Koutrakis P, Tarantini L, Litonjua A, Sparrow D, Vokonas P, Schwartz JD. Epigenetic influences on associations between air pollutants and lung function in elderly men: the normative aging study. Environ Health Perspect. 2014 Jun;122(6):566-72. https://doi.org/10.1289/ehp.1206458

Lepeule J, Laden F, Dockery D, Schwartz J. Chronic Exposure to Fine Particles and Mortality: An Extended Follow-up of the Harvard Six Cities Study from 1974 to 2009. 2012. Environ Health Perspect. Jul;120(7):965-70. https://doi.org/10.1289/ehp.1104660