johanna lepeule Environmental epidemiologist, PhD
Course and current status
Current position
Researcher, INSERM U1209, IAB (Intsitute for Advanced Biosciences), Team EDES (Environmental Epidemiology Applied to Development and Respiratory Health)
Major research interests
Effects of early exposure to environmental factors related to the urban exposome (ie. air pollutants, weather conditions), on the health of the mother and development of the child.
Epigenetic marks as potential biomarkers or mediators of the health effects of environmental exposures.
Education
2021 - HDR, Environmental epidemiology - University of Grenoble
2007 - Ph.D, Veterinary epidemiology - University of Rennes 1
2004 - M.S., Biostatistics - University of Paris-Sud 11
2003 - M.S., Public health - University of Bordeaux
2001 - B.S., Statistics, informatics - University of Grenoble
Appointments
2013-now - Researcher, INSERM, Environmental epidemiology, Grenoble, France
2013-15 - Visiting Scientist, Harvard School of Public Health, Environmental health, Boston, USA
2010-13 - Postdoctoral fellow, Harvard School of Public Health, Environmental health, Boston, USA
2008-10 - Postdoctoral fellow, INSERM, Environmental epidemiology, Grenoble, France
2007-08 - Research assistant, INRA - Veterinary school Veterinary epidemiology, Nantes, France
2004-07 - PhD student, INRA - Veterinary school, Veterinary epidemiology Nantes, France
2004 - Master student, INSERM, Biostatistics, Bordeaux, France
2002-04 - Research assistant, ISPED, Occupational health, Bordeaux, France
National Institute for Health and Medical Research (INSERM U1290), Grenoble, Team of Environmental Epidemiology applied to Development and Respiratory health
Researcher,
Scientific summary
Nakamura A, Broséus L, Tost J, Vaiman D, Martins S, Keyes K, Bonello K, Fekom M, Strandberg-Larsen K, Sutter-Dallay AL, Heude B, Melchior M, Lepeule J. Epigenome-Wide Associations of Placental DNA Methylation and Behavioral and Emotional Difficulties in Children at 3 Years of Age. Int J Mol Sci. 2023 Jul 21;24(14):11772. https://doi.org/10.3390/ijms241411772
Jumentier B, Barrot CC, Estavoyer M, Tost J, Heude B, François O, Lepeule J. High-Dimensional Mediation Analysis: A New Method Applied to Maternal Smoking, Placental DNA Methylation, and Birth Outcomes. 2023. Environ Health Perspect. Apr;131(4):47011. https://doi.org/10.1289/EHP11559
Guilbert A, Bernard JY, Peyre H, Costet N, Hough I, Seyve E, Monfort C, Philippat C, Slama R, Kloog I, Chevrier C, Heude B, Ramus F, Lepeule J. Prenatal and childhood exposure to ambient air pollution and cognitive function in school-age children: Examining sensitive windows and sex-specific associations. Environ Res. 2023 Oct 15;235:116557. https://doi.org/10.1016/j.envres.2023.116557
Guilbert A, Hough I, Seyve E, Rolland M, Quentin J, Slama R, Lyon-Caen S, Kloog I, Bayat S, Siroux V, Lepeule J. Association of Prenatal and Postnatal Exposures to Warm or Cold Air Temperatures With Lung Function in Young Infants. 2023. JAMA Netw Open. Mar 1;6(3):e233376. https://doi.org/10.1001/jamanetworkopen.2023.3376
Lepeule J, Pin I, Boudier A, Quentin J, Lyon-Caen S, Supernant K, Seyve E, Chartier R, Slama R, Siroux V; SEPAGES study group. Pre-natal exposure to NO2 and PM2.5 and newborn lung function: An approach based on repeated personal exposure measurements. Environ Res. 2023 Jun 1;226:115656. https://doi.org/10.1016/j.envres.2023.115656
Hough I, Rolland M, Guilbert A, Seyve E, Heude B, Slama R, Lyon-Caen S, Pin I, Chevrier C, Kloog I, Lepeule J. Early delivery following chronic and acute ambient temperature exposure: a comprehensive survival approach. Int J Epidemiol. 2023 Jun 6;52(3):761-773. https://doi.org/10.1093/ije/dyac190
Broséus L, Vaiman D, Tost J, Martin CRS, Jacobi M, Schwartz JD, Béranger R, Slama R, Heude B, Lepeule J. Maternal blood pressure associates with placental DNA methylation both directly and through alterations in cell-type composition. 2022. BMC Med. Oct 20;20(1):397. https://doi.org/10.1186/s12916-022-02610-y
Jedynak P, Tost J, Calafat AM, Bourova-Flin E, Busato F, Forhan A, Heude B, Jakobi M, Rousseaux S, Schwartz J, Slama R, Vaiman D, Philippat C, Lepeule J. Pregnancy exposure to synthetic phenols and placental DNA methylation - An epigenome-wide association study in male infants from the EDEN cohort. Environ Pollut. 2021 Dec 1;290:118024. https://doi.org/10.1016/j.envpol.2021.118024
Hough I, Sarafian R, Shtein A, Zhou B, Lepeule J*, Kloog I*. Gaussian Markov random fields improve ensemble predictions of daily 1 km PM2.5 and PM10 across France. 2021. Atmos Env. Nov;264:118693. https://doi.org/10.1016/j.atmosenv.2021.118693
Jakpor O, Chevrier C, Kloog I, Benmerad M, Giorgis-Allemand L, Cordier S, Seyve E, Vicedo-Cabrera AM, Slama R, Heude B, Schwartz J, Lepeule J. Term birthweight and critical windows of prenatal exposure to average meteorological conditions and meteorological variability. Environ Int. 2020 Sep;142:105847. https://doi.org/10.1016/j.envint.2020.105847
Everson T*, Vives-Usano M*, Seyve E*, Cardenas A, Lacasaña M, Craig J, Lesseur C, Baker E, Fernandez-Jimenez N, Heude B, Perron H, Gónzalez-Alzaga B, Halliday J, Deyssenroth M, Karagas M, Íñiguez C, Bouchard L, Carmona-Sáez P, Loke Y, Hao K, Belmonte T, Charles MA, Martorell-Marugán J, Muggli E, Chen J, Fernández M, Tost J, Gómez-Martín A, London S, Sunyer J, Marsit C*, Lepeule J*, Hivert MF*, Bustamante M*. Placental DNA methylation signatures of maternal smoking during pregnancy and potential impacts on fetal growth. 2021. Nat Commun. Aug 24;12(1):5095. https://doi.org/10.1038/s41467-021-24558-y
Hough I, Just AC, Zhou B, Dorman M, Lepeule J, Kloog I. A multi-resolution air temperature model for France from MODIS and Landsat thermal data. 2020. Environ Res. Apr;183:109244. https://doi.org/10.1016/j.envres.2020.109244
Rousseaux S, Seyve E, Chuffart F, Bourova-Flin E, Benmerad M, Charles MA, Forhan A, Heude B, Siroux V, Slama R, Tost J, Vaiman D, Khochbin S, Lepeule J. Immediate and durable effects of maternal tobacco consumption alter placental DNA methylation in enhancer and imprinted gene-containing regions. 2020. BMC Med. Oct 7;18(1):306. https://doi.org/10.1186/s12916-020-01736-1
Abraham E, Rousseaux S, Agier L, Giorgis-Allemand L, Tost J, Galineau J, Hulin A, Siroux V, Vaiman D, Charles MA, Heude B, Forhan A, Schwartz J, Chuffart F, Bourova-Flin E, Khochbin S, Slama R, Lepeule J; Pregnancy exposure to atmospheric pollution and meteorological conditions and placental DNA methylation. Environ Int. 2018 Sep;118:334-347. https://doi.org/10.1016/j.envint.2018.05.007
Lepeule J, Bind MA, Baccarelli AA, Koutrakis P, Tarantini L, Litonjua A, Sparrow D, Vokonas P, Schwartz JD. Epigenetic influences on associations between air pollutants and lung function in elderly men: the normative aging study. Environ Health Perspect. 2014 Jun;122(6):566-72. https://doi.org/10.1289/ehp.1206458
Lepeule J, Laden F, Dockery D, Schwartz J. Chronic Exposure to Fine Particles and Mortality: An Extended Follow-up of the Harvard Six Cities Study from 1974 to 2009. 2012. Environ Health Perspect. Jul;120(7):965-70. https://doi.org/10.1289/ehp.1104660
