Pauline Soulas-Sprauel PharmD, PhD Immunology
Course and current status
CURRENT POSITION
Since 2015: Professor Immunology / Faculty of Pharmacy / University of Strasbourg - Hospital practitioner at Clinical Immunology Department, Strasbourg’s Hospital (Strasbourg, France) (PU-PH)
Since 2018: Head of the “lymphocyte homeostasis and autoimmunity” group - (CNRS UPR 3572 unit (Head: Dr Hélène Dumortier) – IBMC institute, Strasbourg until september, 2019 ; Inserm U1109 (Head: Prof Seiamak Bahram) - CRBS (Centre de Recherche en Biomédecine de Strasbourg), Strasbourg, since October, 2019)
Since 2018: Vice-dean of the Faculty of Pharmacy, Strasbourg, France
DEGREES AND TRAINING/POSITIONS:
1998: Diploma in Pharmacy – University of Strasbourg, France. 3rd academic rank after first year examination.
1999: Master of Science in Molecular and Cellular Biology (DEA) – University of Strasbourg, France – 1st academic rank - - Inserm U737 unit, Strasbourg, France
2003: Ph.D. in Immunology – University of Strasbourg, France – mention très honorable - Inserm U737 unit, Strasbourg, France
2003-2006: Postdoctoral stay with Dr Jean-Pierre de Villartay - Inserm U768, Necker Hospital, Paris, France (Head: Prof. Alain Fischer)
2006-2007 : AHU (university hospital assistant) in Immunology, Strasbourg Hospital & Faculty of Pharmacy, Strasbourg, France
2007-2011 : Assistant professor (MCF) in Immunology - Faculty of Pharmacy, Strasbourg, France - Inserm U737, Strasbourg, FRance (Head: Prof Thierry Martin)
2010: H.D.R. (Habilitation à Diriger des Recherches) - University of Strasbourg, France
2011-2015 : Assistant professor & hospital pratictioner (MCU-PH) in Immunology - Strasbourg Hospital (Clinical immunology department), Faculty of Pharmacy & CNRS UPR9021 (IBMC) (Head: Dr Sylviane Muller), Strasbourg, France
Scientific summary
My research group focuses on the basic mechanisms ensuring B- and T-cell homeostasis. We closely investigate tolerance breakdown leading to the development of autoimmunity during autoimmune diseases (in particular systemic lupus erythematosus (SLE), antiphospholipid syndrome, and systemic sclerosis) and during primary immunodeficiencies, using murine models (cell lines, transgenic mice) as well as human samples from patients. We also investigate the role of the autophagy machinery in these contexts. Our research is facilitated by our close collaboration with the Department of Clinical Immunology and Internal Medicine (Strasbourg University Hospital; Head: Pr. Anne-Sophie Korganow) and the French National reference center for systemic autoimmune diseases East South-West (RESO) (Head: Pr Thierry Martin).
The group is composed of 7 permanent researchers (2 PU-PH-MD, 1 PU-PH-PharmD, 1 MCU-PH-MD, 1 MCU-PH-dental surgery, 1 MCU-PH-PharmD, and 1 MCU), 2 engineers and students.
I am currently conducting the following research projects:
- Consequences of STING gain of function on the development and phenotype of lymphocytes (CrisprCas9 mouse model) (ANR Lymphosting)
- Role of ERN1 in lymphocyte homeostasis and autoimmunity (CrisprCas9 mouse model) (ANR Lumugene, ended)
I am participating in the following research project :
- Molecular and cellular characterization of CXCR4-mediated immunomodulation: implication in autoimmune diseases (ANR X4Inflam)
