Renald Delanoue PhD in developmental biology

Course and current status

- PhD (1997-2001) at the university of Paris 7 in Pr J. Silber's lab (IJM, Paris): Deciphering the role of the vestigial gene in controlling cell proliferation and growth in developing appendages of Drosophila melanogaster.

 - Post-doctoral studies (2001-2002) at the IGMC (Strasbourg) in Dr A. Giangrande’s lab : Role of the GCM protein family in glial differentiation

 - Post-doctoral studies (2002-2006) at the Wellcome Trust Center for Cell Biology (University of Edinburgh-UK) in Pr I. Davis’ lab: Mechanisms of mRNA intracellular transport in Drosophila.

 - INSERM Researcher (2006-2018) in Pr P. Léopold’s team (iBV, Nice): The regulation of the systemic growth and developmental timing by nutrition in Drosophila.

 - INSERM Researcher (2018-present) in Dr B. Hudry team (iBV, Nice) : Impact of the cellular sex on animal physiology.

Scientific summary

I did my PhD in developmental biology at the Institut Jacques Monod (Paris). My aim was to understand how genes involved in wing morphogenesis control cell proliferation and growth during appendage development using Drosophila melanogaster as a model.

Then, during my post doc at the university of Edinburgh, I studied mechanisms involved in intracellular mRNA transport. I showed that in addition to their documented role in intracellular transport, molecular motors, such as dynein, were also required for the tethering of the transcripts at their site of function. Moreover, I showed that transcripts are transported to their final destination in non-membrane-bound, nonmembrane transport particles directly associated with microtubules and then statically anchored in large cytoplasmic structures, subsequently named P bodies by additional research in the field. I showed that molecular motors are also important for the integrity of these storage structures.

I was recruited by INSERM and joined the group of Pr P. Léopold at the iBV (Nice). I developed projects to understand how nutritional input is integrated to adjust general body growth and final size. I identified key molecules and regulation mechanisms important for these interorgan communications. Specifically, I unravel the role of a mitochondrial protein, secreted and involved in the systemic control of insulin secretion by nutrition. In addition, we uncovered a complex neuronal circuitry essential to couple insulin secretion with food quality during animal development.

I recently joined the team of B. Hudry (iBV) to study the impact of cellular sex on animal physiology. I developed two projects: 1- evaluating the impact of sex chromosome architecture on cell and animal physiology; 2- deciphering the mechanisms involved in sex-biased tumor appearance and progression.

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