• E-mail :[email]
  • Phone : 0679538522
  • Location : Rennes, France
Last update 2022-01-12 15:34:25.179

Grégoire Michaux Dynamics of epithelial polarity

Course and current status

Main responsibilities
From 2007: PI: Dynamics of epithelial polarity - IGDR
From 2015: Electron microscopy facility scientific coordinator - MRic
2019-2021: Scientific integrity officer - IGDR
2016-2019: PhD program coordinator - IGDR
2013-2016: Cell Biology and Development Department coordinator – IGDR
2008-2015: French Society for Cell Biology board member

Education and training
2007: Habilitation à Diriger les Recherches, Université de Rennes 1
2002-2006: Postdoctoral position in the group of Dan Cutler, MRC LMCB, London, UK.
1998-2001: PhD in the group of Michel Labouesse, IGBMC, Strasbourg.

Scientific summary

The intestine performs one of the most essential functions of an animal organism, food absorption. We investigate three key aspects of the making of an intestine:

- Dynamics of the absorptive apical membrane

Control of intestinal cell proliferation and terminal differentiation

Coordinated intestinal morphogenesis

To answer these questions, we undertake a multiscale approach, from molecules to whole organism, using C. elegans as a model organism and intestinal organoids a mammalian model. Moreover, our collaborations with physicians allow us to address the clinical relevance of our discoveries. Our main tools are cutting-edge microscopy (Zeiss Airyscan, Random illumination Microscopy, laser nanoablations), and advanced genetic methods (endogenously tagged genes, time-/tissue-specific degrons, gene editing).

Image d’exemple