CV Science

Bénédicte Chazaud Stem cell environment and skeletal muscle homeostasis

Course and current status

2016/now - Leader of the team "Stem cell environment and skeletal muscle homeostasis" at Institut NeuroMyoGène, CNRS 5310, INSERM 1217, Université Claude Bernard Lyon 1, then CNRS 5261, INSERM 1315

2018 - Director of Research (DR1) INSERM

2013/15 - Team leader "Stem cell environment and skeletal muscle homeostasis" at Institut Cochin, Paris INSERM U1016, CNRS 8104, Univ. Paris Descartes, then at CGjPMC, CNRS 5534, Univ. Claude Bernard Lyon 1

2010 - Director of Research (DR2) INSERM

2008/12 - Group leader in the team "Genetics and pathophysiology of neurodevelopmental and neuromuscular diseases", Institut Cochin, Paris

2004/08 - Researcher in the laboratory Cell interactions in the neuromuscular system, Institut Mondor de Recherche Biomédicale, Créteil (INSERM U841, Université Paris Est-Créteil)

2004 - Habilitation (Habilitation à Diriger les Recherches), Université Paris Est-Créteil

2004 - Tenure researcher (Chargé de Recherches) INSERM

1996/03- Post doc in the Research group on muscle and nerve (INSERM EMI-0011, Université Paris Est-Créteil).

1994/96 - Part-time lecturer, Université Paris Descartes

1995 - PhD in Life Sciences, Cell Biology, Université Paris Descartes

Scientific summary

Skeletal muscle is a highly adaptable tissue with well-known sensitivities to environmental cues such as growth factors, cytokines, nutrients and mechanical loading. Moreover, adult skeletal muscle exhibits great plasticity and has the unique capacity to regenerate after injury, due to the main muscle stem cells, the satellite cells. Satellite cells, and their progeny, the myogenic precursor cells, must develop proper interactions with their direct environment to ensure muscle regeneration and replenishment of the stem cell pool. The aim of our research is to understand the role of the environment of muscle stem cells in the regulation of skeletal muscle regeneration. Myogenic cell environment includes inflammatory cells and particularly macrophages, vessel cells (endothelial and peri-endothelial cells) and interstitial cells. Moreover, we aim at understanding the interactions between myogenic cells and their environment in various pathological situations.