Scientific topics
Keywords
ITMO
Sylvain RHEIMS MD-PhD, Professor of Neurology
Course and current status
1. PERSONAL INFORMATION
Family name, First name: RHEIMS Sylvain
Researcher unique identifier: https://orcid.org/0000-0002-4663-8515
Date of birth: April 22nd 1979
Nationality: French
URL for web site: www.sylvain-rheims.fr
2. EDUCATION
Science
2015 HDR (Habilitation thesis), University of Lyon
2009 PhD in Neurosciences. Mediterranean Institute for Neurobiology. Aix-Marseille University
2005 Master 2 in Neurobiology, Aix-Marseille University
2001 Master 1 in Neurobiology, Louis Pasteur University, Strasbourg
Medicine
2011 Certification in Clinical Neurophysiology, University of Lyon
2010 MD degree and habilitation in Neurology. University of Lyon
2009 Certification in Epileptology, University of Nancy
2003-2008 Neurology residency (Lyon)
2003 National selection to Medical Internship (France, Rank: 1st / > 4000 candidates).
1997-2003 Medical school: Louis Pasteur University, Strasbourg (France)
3. CURRENT POSITIONS
Since 2016 Professor of Neurology, Department of functional Neurology and Epileptology, Hospices Civils de Lyon (HCL) and University of Lyon 1 (UCBL), Lyon, France
- Science position: Co-leader of the Epilepsy Team within the Lyon’s Neuroscience Research Center (Team TIGER, INSERM U1028 / CNRS UMR 5292 / UCBL), France
- Clinical position: Head of Department of Functional Neurology and Epileptology, HCL, France
4. PREVIOUS POSITIONS
2013-2016 Associate Professor of Neurology. Department of functional Neurology and Epileptology, HCL and UCBL, Lyon, France.
2011-2016 PI: Team TIGER within the Lyon’s Neuroscience Research Center (INSERM U1028 / CNRS UMR 5292 / UCBL), France
2010 – 2013 Assistant professor of Neurology, Department of Functional Neurology and Epileptology, HCL and UCBL, Lyon, France
2005 – 2008 “Poste d’accueil INSERM”, INSERM U901, Mediterranean Institute for Neurobiology (INMED). Dr Y. Ben Ari, Marseille, France
2003 – 2010 Resident, Neurological Hospital, HCL, Lyon, France
5. AWARDS
2021 Doctoral and research supervision award (PEDR) from the National Council of Universities for Neurology
2018 European Young Investigator Award of the International League Against Epilepsy
6. INSTITUTIONAL RESPONSIBILITIES
Science
- Member of the INSERM Neuroscience scientific commission (CSS4) (Since 2022)
- Member of the research steering committee of the Hospices Civils de Lyon (Since 2021)
- Member of the expert panel of the ITMO Neurosciences (INSERM/CNRS) (Since 2020)
- Member of the SAB of the start-up GAOMA therapeutics developing drugs for epilepsies (Since 2019)
- Co-Head of the clinical research unit at Neurological Hospital, Hospices Civils de Lyon (Since 2017)
- Co-head of the intra-cerebral EEG (iEEG) platform of the IHU CESAME and of CRNL (Since 2015)
- Member of the Clinical Research Council of the Hospices Civils de Lyon (HCL) (2011-2020)
Medicine
- Head of the Department of Functional Neurology and Epileptology at Hospices Civils de Lyon (Since 2015)
- Head of the national reference center for rare epilepsies at Hospices Civils de Lyon (Since 2017)
Other
- Director of the Epilepsy Institute IDEE, Lyon (since 2018)
- Vice-President of the French League Against Epilepsy in charge of scientific affairs (since 2017)
- Member of the board of the French Society of Neurology (2016-2020)
Scientific summary
1. SUMMARY
Pr. Sylvain Rheims, 43 years old, is full professor of Neurology at University of Lyon, head of Department of Functional Neurology and Epilepsy in Lyon, one of the most active epilepsy surgery center in Europe, and co-chair of an INSERM/CNRS laboratory specialized in translational research in epilepsy (TIGER, CRNL, INSERM U1025, CNRS 5292). He coordinates in Lyon the French National Reference Center for Rare Epilepsies and is deeply involved in the European Reference Network for rare and complex epilepsies (EPICARE), especially in the field of epilepsy surgery and clinical trials.
His clinical research skills cover both the fields of clinical epilepsy, including SUDEP, epilepsy surgery and clinical trials, but also biostatistics (including meta-analysis), and experimental epilepsy. His main research topics are evaluation of efficacy and safety of new antiepileptic treatments and development of innovative therapeutic strategies for epilepsy comorbidities, especially in the field of SUDEP, which has progressively become his main research axis. He received in 2018 the ILAE-CEA European Young Investigator Award.
2. GRANTS AND PROJECTS
- 2011 French Ministry of Health, PHRC national: Efficacy of n-3 polyunsaturated fatty acids supplementation on attention disorders in children with epilepsy. A multicenter double-blind placebo controlled trial. Role: PI (647K€)
- 20212 Regional Young researcher Grant: Implication of serotoninergic regulation of respiratory rhythms in Sudden Unexpected Death in Epilepsy. Role: PI (20K€)
- 2013 French Ministry of Health, PHRC national (430K€): Efficacy of Naloxone in reducing postictal central respiratory dysfunction in patients with epilepsy. A multicenter double-blind placebo controlled trial. Role: PI (430K€)
- 2013 French Ministry of Health, PHRC national SAVE: Safety of antiepileptic drug withdrawal in long term video-EEG monitoring. Role: Co-PI (461K€).
- 2017 French Ministry of Research and French Ministry of Health: Improving EPilepsy surgery management and progNOsis using Virtual brain technology (EPINOV). Role: Partner (402 k€)
- 2017 INSERM, Contrat d’interface 2017: Mechanisms and risk factor of SUDEP. Role: PI (110 k€)
- 2018 French Foundation against Epilepsy : Circulating microRNAs as biomarkers of RESPIratory dysfunction in patients with refractory epilepsy. Role: PI (68k€)
- 2019 FLAG-ERA JTC : Advanced Morphological Reconstruction of Human Brain Tissue by Multimodal Fusion of Multiscale Optical Imaging Technologies (SMART BRAIN). Role Partner (160k€)
- 2021 French Agency for Research (ANR): Relation between serotoninergic brainstem dysfunction and epilepsy-related respiratory dysfunction in Dravet syndrome: (seroDRAVET). Role: PI (499k€)
- 2021 ERANET NEURON: Neurodevelopmental impact of epilepsy on autonomic function in Dravet Syndrome (AUTONOMIC): Role PI (1 069 k€)
3. PUBLICATIONS
142 peer-reviewed publications including 33 as a first author and 34 as senior author and/or corresponding author
3615 citations (citations without self-citations: 3452), average citations per item: 23.03 h-index: 30 (as of 24/01/2022, source Web of Science)
Main publications
Ryvlin P, Rheims S, Hirsch LJ, Sokolov A, and Jehi L. Neuromodulation in epilepsy: state-of-the-art approved therapies. Lancet Neurol 2021;20:1038-47.
Loizon M, Ryvlin P, Chatard B, Jung J, Bouet R, Guenot M, Mazzola L, Bezin L, Rheims S. Transient hypoxemia induced by cortical stimulation: a mapping study in 75 patients. Neurology 2020. 94:e2323-36..
Domenech P, Rheims S, and Koechlin E. Neural mechanisms resolving exploitation-exploration dilemmas in the medial prefrontal cortex. Science 2020;369
Rheims, S., B. M. Alvarez, V. Alexandre, J. Curot, L. Maillard, F. Bartolomei, P. Derambure, E. Hirsch, V. Michel, F. Chassoux, D. Tourniaire, A. Crespel, A. Biraben, V. Navarro, P. Kahane, B. De Toffol, P. Thomas, S. Rosenberg, L. Valton, L. Bezin, P. Ryvlin, and S. G.. Hypoxemia Following Generalized Convulsive Seizures: Risk Factors and Effect of Oxygen Therapy. Neurology 2019. 92(3): e183-93.
Ryvlin P*, Cross JH*, Rheims S*. Epilepsy surgery in children and adults. Lancet Neurol. 2014 Nov;13(11):1114-26
Ryvlin P*, Cucherat M, Rheims S*. Risk of sudden unexpected death in epilepsy in patients given adjunctive antiepileptic treatment for refractory seizures: a meta-analysis of placebo-controlled randomised trials. Lancet Neurol. 2011 Nov;10(11):961-8.
Rheims S, Cucherat M, Arzimanoglou A, Ryvlin P. Greater response to placebo in children than in adults: a systematic review and meta-analysis in drug-resistant partial epilepsy. PLoS Med 2008. 5(8): e166
