Sophie Peron Mechanisms of genetic instability underlying transformation and tumor evolution in chronic lymphocytic leukemia
Course and current status
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Since 2019: Head of the research focus "Mechanisms of genetic instability underlying transformation and tumor evolution in chronic lymphocytic leukemia"
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2014–2018: Researcher in Prof. Cogné’s team, CRIBL Laboratory
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Since 2013: INSERM Research Scientist
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2009–2013: Postdoctoral researcher, UMR CNRS 7276 CRIBL Laboratory
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2004–2008: PhD in Immunology, University Paris VII and Inserm U768 (Supervisor: Prof. A. Fischer), Necker Hospital, Paris.
Thesis title: “Molecular characterization of inherited immunoglobulin class switch recombination deficiencies” (Advisor: Dr. Anne Durandy) -
2003–2004: DEA in Advanced Immunology, University Paris VI and Institut Pasteur, Paris
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1999–2003: DEUG, Bachelor’s and Master’s in Biochemistry with a specialization in immunology and microbial biochemistry, University of Poitiers
Scientific summary
Research Activity
We investigate the fundamental mechanisms involved in the tumor transformation of B cells, particularly in chronic lymphocytic leukemia (CLL) and B-cell non-Hodgkin lymphomas associated with MYC overexpression. Our work focuses on mechanisms that normally ensure genomic stability, from nuclear organization to DNA repair processes.
Ongoing Projects
MYC-3DB
Study of the impact of MYC overexpression on 3D chromatin organization and transcriptomic deregulation in B cells to better understand the pathophysiology of B-cell cancers associated with MYC overexpression
Principal Investigator: Sophie Peron
Funding: Haute Vienne Committee of the French Cancer League, Nouvelle-Aquitaine Region, Omegahealth Institute, University of Limoges, and Cancéropôle Grand Sud-Ouest
Collaborations: Manuel Diaz Muñoz (INFINITY, Toulouse), Saïd Aoufouchi (Gustave Roussy, Villejuif), Biola Javierre (Josep Carreras Leukemia Research Institute, Barcelona)
PROMISE
Use of the mini-protein Omomyc to inhibit survival and expansion of chronic lymphocytic leukemia tumor cells
Principal Investigator: Sophie Peron
Collaborators: Laura Soucek and Jonathan Whitfield, VHIO, Barcelona
DALIPT
Decoding genetic alterations in chronic lymphocytic leukemia: implications for prognosis and therapeutic strategies
Principal Investigators: Jasmine Chauzeix, Nathalie Gachard, and Sophie Peron
Funding: Haute Vienne Committee of the French Cancer League
EVOLLC
This project aims to understand how genomic instability influences the evolution of chronic lymphocytic leukemia by characterizing specific patient subgroups and identifying new therapeutic targets
Principal Investigators: Nathalie Gachard and Sophie Peron
Funding: Haute Vienne Committee of the French Cancer League
Associated Personnel
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Nathalie Gachard (Hospital Practitioner, Department of Hematology)
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David Rizzo (Associate Professor-Hospital Practitioner, Department of Hematology)
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Jasmine Chauzeix (Associate Professor-Hospital Practitioner, Department of Hematology)
Anna Cracco, Master’s student (2nd year), 2025
Alumni
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Kenza Guiyedi, Master’s 2023; PhD student 2021–2024
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Milène Parquet, PhD student 2021–2024
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Maxime Roubinet, Master’s 2024
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Marie Lambert, Master’s (1st year), 2023
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Clément Farout, Master’s (1st year), 2023
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Israa Al Jamal, PhD student 2019–2022
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Hend Boutouil, Master’s 2014; PhD student 2015–2018
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Ophélie Téteau, Master’s (1st year), 2016
Resources
CSReport software (Boyer et al., J Immunol. 2017) enables the analysis of high-throughput sequencing data from PCR-amplified IgH locus recombination junctions.
CSReport requires Python3 and Jupyter environments (preferably via Anaconda distribution) with an up-to-date Biopython package.
CSReport works with a custom reference (derived from NCBI sources) of a constant IgH locus sequence and annotations for human or mouse models. The reference must match the model organism.
The CSReport notebook file (ZIP archive), including reference files, is available upon email request.
