CV Science

Thomas CLOUAIRE Thomas Clouaire, PhD in Molecular Biology, INSERM CRCN

Course and current status

Currently (since 2015) : Principal Investigator (INSERM CRCN), Chromatin and DNA repair team (headed by Gaelle Legube)
Molecular, cellular and Developmental biology unit (MCD), Centre de Biologie Integrative (CBI), Toulouse, FR

2013-2015 : Postdoctoral fellow
Laboratoire de biologie cellulaire et moléculaire du contrôle de la prolifération (LBCMCP), Toulouse, FR

2006-2013 : Postdoctoral fellow
Wellcome Trust Centre for Cell Biology, University of Edinburgh, UK

2001-2005 : PhD in Molecular Biology
Institut de Pharmacologie et de Biologie Strcutrale (IPBS), Toulouse, FR

Scientific summary

In eukaryotes, DNA is embedded into chromatin, which makes for both a precisely arranged and yet very dynamic environment. This fascinating structure is organized on many different levels and over a variety of tightly interconnected scales.

My research is focused on understanding how chromatin structure and epigenetic information influences basic processes such as gene expression and genome stability.
More precisely, our team is investigating chromosome dynamics in response to DNA double-strand breaks, which are very toxic DNA lesions, using a variey of high-resolution genomics approaches in mammalian cells.