Scientific topics
Keywords
ITMO
olivier destaing PhD cell sciences and cell biology
Course and current status
2021 DR2 CNRS, Dysad - Inserm U1209 CNRS UMR 5309, Institute for Advanced Biosciences, Grenoble, France
2012 HDR (Habilitation à diriger les recherches), Faculté de pharmacie, Université Joseph Fourier, Grenoble, France
2012-2021 CR1 CNRS,Dysad - Inserm U1209 CNRS UMR 5309, Institute for Advanced Biosciences, Grenoble, France
2008-2012 CR2 CNRS, Dysad - ERL 5284 Institut Albert Bonniot, Grenoble, France.
2008 Stage post-doctoral II (Grant CNRS). Equipe Dysad,(‘Dynamic of adhesive and differentiation system’), Grenoble, France (dirigé par C. Albiges-Rizo).
2004-2008 Stage post-doctoral I. Yale Medical School, New Haven, USA (dirigé par: Profs DeCamilli and Baron).
2003 Doctorat de l’Ecole Normale Supérieure de Lyon, option biologie cellulaire. Equipe de P. Jurdic. Ecole Normale Supérieure (ENS), Lyon, France.
Scientific summary
My research has shown that invadosms have two seemingly antagonistic functions: that of adhesion and protrusion orthogonal to the extracellular matrix which is dependent on the polymerization of actin (acto-adhesive function) and that of degradation of the extracellular matrix. Today, I would like to continue to identify the regulators of this coupling, the sensors, the signaling pathways and the effectors involved in the coordination of these two functions. I propose to focus on the kinases of the SRC family in this process which are essential elements for invadosomes and which present a great functional pleitropy that can regulate multiple functions in parallel. The invadosome also seems to me to be a very interesting minimal model to better understand the molecular principles of the decision-making of a signaling element that leads to the activation/inhibition of different cellular structures. My research project is based on the coexistence of 4 scientific axes and will require new specific technological developments in microscopy and optogenetics, in particular.
