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  • Phone : + 33 6 63 64 46 97
  • Location : gif sur yvette, France
Last update 2022-03-04 10:36:07.645

Catherine GUILLOU Research Director CNRS first classe, medicinal and organic chemistry

Course and current status


2021: Appointed deputy coordinator of the interdisciplinary Healthi object (Network of research in health and therapeutic innovation, bringing together 2080 people, 62% of whom are permanent staff)
2021: Appointed member of the scientific council of the graduate school of chemistry of the University Paris-Saclay
2020: Coordinator of the "Natural substances and medicinal chemistry" department of ICSN
2013-2021 : Appointed member of the scientific council of the chemistry department of the Paris-Saclay University
2018- : Research Director (DR1) at ICSN
2012-2020 : Member of the Labex Lermit (Laboratory of excellence in drug research and therapeutic innovation)
2012-2016 : Consultant for Biokinesis
06/2010 - : Director of the ICSN chemical library

2008-2011: Appointed Member of the National Council of Universities (CNU) section 32

2004-2018 : Research Director (DR2) at ICSN

1997-2004 : Chargé de recherche (CR1) CNRS at the same laboratory

1993-1997 : Chargé de recherche (CR2) CNRS in the UPR 2301-ICSN unit

1992-1993 : Post-doctoral internship C.E.A., Research laboratory of the Service des   Molécules Marquées, Saclay ; Direction : C. Mioskowski and J. P. Lellouche

Academic Background
1999 : HDR, Orsay University (Paris XI)
1988-1991 : PhD in Chemistry, Orsay University (Paris XI), PhD supervisors : P. Potier and C. Thal CNRS, ICSN
1988 : Master in Organic Chemistry,  Orsay University (Paris XI)
1987 : Master in Biochemistry,  P. et M. Curie University  (Paris VI)

Scientific summary

Since my recruitment at the CNRS in October 1993, I have been interested in medicinal chemistry, the total synthesis of biologically active natural products, and organometallic chemistry. We have performed structure-activity relationships in medicinal chemistry on acetylcholinesterase inhibitors (galanthamine series, tetracyclic triterpenes, and iminosugars), kinase, kinesins myosins inhibitors, and nicotinic receptor antagonists. In total synthesis, we have carried out those of several natural products: galanthamine, crinine, maritidine, codeine, analogues of Buchi's ketone. More recently I have been involved in the synthesis of (-)-gymnodimine A, 13-desmethyl spirolide C and sarniensine. I have worked with different metals, iron, palladium, copper, rhodium in organometallic chemistry and carried out methodology studies. Some of my results have led to several patents and licenses and the creation of a start-up (Biokinesis end of 2011). Since 2010, I have been in charge of the ICSN chemical library.

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