CV Science

Juan Reguera PhD, HDR Biochemistry and molecular biology

Course and current status

2021                  Research Director (DR2) at the Architecture and Function of Biological Macromolecules laboratory (AFMB, UMR7257) by the National Institute for Health and Medical Research (INSERM), Marseille, France.   

2016                  Group Leader at the AFMB UMR7257 laboratory, National Center for Scientific Research (CNRS) and Aix-Marseille University (AMU), Marseille, France.

2016 - 2021        Research scientist (CR1) at the Architecture and Function of Biological Macromolecules laboratory (AFMB, UMR7257) by the National Institute for Health and Medical Research (INSERM), Marseille, France.

2013 – 2016       Research Scientist (EMBL) at the Stephen Cusack’s laboratory, European Molecular Biology Laboratory and the International Unit for Virus Host-Cell Interactions (UVHCI) UMI3265, Grenoble, France.

2009 – 2013          Post-Doctoral position at the Stephen Cusack’s laboratory, European Molecular Biology Laboratory and the International Unit for Virus Host-Cell Interactions (UVHCI) UMI3265, Grenoble, France.

2006 – 2009           Post-Doctoral position at the Department of Macromolecular Structures, National Center for Biotechnology (CNB), Spanish Council for the Scientific Research (CSIC), Madrid, Spain.

2005 – 2006          Post-Doctoral position at the Department of molecular and cellular biology, CNB-CSIC, Madrid, Spain.

2000 – 2004           PhD student at the Center for Molecular Biology “Severo Ochoa” (CBM-SO), CSIC/UAM, Madrid, Spain.

Scientific summary

My team focuses on understanding viral and pseudo-viral infection mechanisms, mainly ruled by the interplay of viral proteins, cellular factors and nucleic acids assembled into multifunctional complexes. In some cases, like many positive stranded RNA viruses, replication is associated to the generation of membrane organelles where replication and transcription occur. Our aim is to understand the mechanisms by which the multiple enzymatic activities are coordinated and regulated to efficiently carry out infection. For this purpose, understanding the interactions of viral proteins with cellular protein factors and membranes is crucial. To reach our goals we use a broad range of biochemical and biophysical technics combined with X-ray crystallography and electron microscopy.