Gwenaëlle André PhD Computational Biology

Course and current status

PhD in Computational Biology INRA Nantes University

Visiting Assistant Professor at Cornell University NY USA

Junior Scientist INRA Nantes

Senior Scientist Institut Pasteur Paris

Research Director INRAE Jouy-en-Josas

HDR in Computational biology of signalling proteins

ORCID 0000-0001-6814-7859

Scientific summary

I work as a structural computational biologist at INRAE, on the Campus of Jouy-en-Josas, in MaIAGE: Applied Mathematics and Computer Science, from Genome to Environment. This lab is headed by Dr. S. Schbath, and has a co-sharing divisions of MIA (Applied Mathematics and Informatics) and MICA (Microbiology and Food Chain). I belong to the StatInfoMics team headed by Dr. P. Nicolas.

My interests deal with i) the functional and structural profiling of Mfd a bacterial nanomachine protein which is an evolvability and a virulence factor for antibiotic resistance and ii) computational screening of whole genomes and metagenomes to infer proteins structures and functional annotations. I have special focus on proteins of the gut microbiome which are involved in biomedical properties such as host-pathogen or anti-inflammatory signaling. My primary interest deals with  prokaryotic signaling through phosphorylation and dephosphorylation events, mediated by protein Ser/Thr kinases and protein Tyr phosphatases, respectively. I also have fruitful collaborations with biologists from Micalis-INRA, IPBS Toulouse or collaborators from South America and I aim to infer on the combo sequence/structure/function/dynamics for the analysis of their favorite protein(s).

For all my projects, i combine structural and computational bioinformatics, molecular modeling expertise, X-ray crystallography skills, with in vitro/in vivo data from my collaborators, whose methods span biophysics, biochemistry, cellular biology, neurobiology, and immunology.

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